Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
2-hydroxyglutaric aciduria +   
adrenoleukodystrophy +   
Asparagine Synthetase Deficiency  
branched-chain keto acid dehydrogenase kinase deficiency  
cerebral creatine deficiency syndrome 1  
COX deficiency, benign infantile mitochondrial myopathy +   
COX deficiency, infantile mitochondrial myopathy +   
CST3-related cerebral amyloid angiopathy +   
Defect of Tricarboxylic Acid Cycle 
Encephalopathy due to Defective Mitochondrial and Peroxisomal Fission +   
ENCEPHALOPATHY, PORPHYRIA-RELATED  
Encephalopathy, Spastic Tetraparesis, and Hypogonadism 
galactosemia +   
glycine encephalopathy +   
Hartnup disease  
Hereditary Central Nervous System Demyelinating Diseases +   
homocarnosinosis  
homocystinuria +   
Hyperglycinemia, Lactic Acidosis, and Seizures  
hyperlysinemia +   
Leigh disease +   
A cytochrome-c oxidase deficiency disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. (DO)
Lesch-Nyhan syndrome +   
Lysosomal Storage Diseases, Nervous System +   
maple syrup urine disease +   
MELAS syndrome +   
Menkes disease +   
MERRF Syndrome +   
mevalonic aciduria  
Microphthalmia and Mental Deficiency 
mitochondrial complex IV deficiency nuclear type 23  
mitochondrial pyruvate carrier deficiency  
oculocerebrorenal syndrome +   
phenylketonuria +   
pyruvate carboxylase deficiency disease +   
pyruvate decarboxylase deficiency +   
pyruvate kinase deficiency of red cells  
Recurrent Metabolic Crises with Variable Encephalomyopathic Features and Neurologic Regression  
Refsum disease +   
Silengo Lerone Pelizza Syndrome 
tyrosinemia +   
urea cycle disorder +   
Wilson disease +   
Zellweger syndrome +   

Synonyms
Exact Synonyms: Infantile Subacute Necrotizing Encephalopathy ;   Juvenile Leigh Disease ;   Juvenile Subacute Necrotizing Encephalopathy ;   LS ;   Leigh Syndrome ;   Leigh's Disease ;   Leighs Disease ;   Subacute Necrotizing Encephalomyelitis ;   Subacute Necrotizing Encephalomyelitis, Infantile ;   Subacute Necrotizing Encephalomyelopathies ;   Subacute Necrotizing Encephalomyelopathy ;   infantile Leigh disease ;   infantile necrotizing encephalomyelopathy ;   juvenile subacute necrotizing encephalomyelopathy ;   subacute necrotising encephalopathy of Leigh ;   subacute necrotizing encephalomyelitides ;   subacute necrotizing encephalopathies ;   subacute necrotizing encephalopathy
Primary IDs: MESH:D007888
Alternate IDs: OMIA:001097 ;   OMIM:256000
Xrefs: GARD:6877 ;   ICD10CM:G31.82 ;   NCI:C84814 ;   ORDO:506
Definition Sources: http://en.wikipedia.org/wiki/Leigh%27s_disease "DO" "DO", http://ghr.nlm.nih.gov/condition/leigh-syndrome "DO" "DO", https://rarediseases.org/rare-diseases/cytochrome-c-oxidase-deficiency/ "DO" "DO", https://rarediseases.org/rare-diseases/leigh-syndrome/ "DO" "DO"

paths to the root