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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:doxepin drug pathway
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Accession:PW:0002310 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of desipramine, an antidepressant used in the treatment of depression, anxiety disorders, insomnia. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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doxepin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00641 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 ISO SMPDB SMP:00641 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 ISO SMPDB SMP:00641 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 ISO SMPDB SMP:00641 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO SMPDB SMP:00641 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 ISO SMPDB SMP:00641 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6070
    drug pathway 402
      nervous system drug pathway 190
        antidepressant drug pathway 41
          non-selective monoamine reuptake inhibitor drug pathway 36
            doxepin drug pathway 6
              doxepin pharmacodynamics pathway 0
              doxepin pharmacokinetics pathway 6
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