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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tenofovir drug pathway
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Accession:PW:0001771 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of tenofovir, an antirfetroviral drug used for the treatment of HIV infection and hepatitis B. It is a nucleoside analog reverse transcriptase inhibitor. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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tenofovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK1 adenylate kinase 1 ISO SMPDB SMP:00630 NCBI chr 9:55,539,179...55,548,132
Ensembl chr 9:55,539,260...55,548,132 		JBrowse link
G AK2 adenylate kinase 2 ISO SMPDB SMP:00630 NCBI chr 2:68,342,769...68,371,769
Ensembl chr 2:68,350,057...68,371,090 		JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO SMPDB SMP:00630 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955 		JBrowse link
G NME2 non-metastatic cells 2, protein (NM23B) expressed in ISO SMPDB SMP:00630 NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    drug pathway 379
      anti-infective drug pathway 27
        tenofovir drug pathway 4
          tenofovir pharmacodynamics pathway 0
          tenofovir pharmacokinetics pathway 4
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