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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:anti-infective drug pathway
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Accession:PW:0000996 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of compounds used as anti-infective agents. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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adefovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak1 adenylate kinase 1 ISO SMPDB SMP:00629 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Ak2 adenylate kinase 2 ISO SMPDB SMP:00629 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00629 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO SMPDB SMP:00629 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538 		JBrowse link
lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00649 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00649 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 ISO SMPDB SMP:00649 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO SMPDB SMP:00649 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Chpt1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830 		JBrowse link
G Dck deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr10:100,739,591...100,742,276
Ensembl chr10:100,739,588...100,741,954 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr10:105,888,769...105,896,182
Ensembl chr10:105,888,775...105,896,172 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00649 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
neviparine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00642 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 ISO SMPDB SMP:00642 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00642 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00642 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00642 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 ISO SMPDB SMP:00642 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
tenofovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak1 adenylate kinase 1 ISO SMPDB SMP:00630 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Ak2 adenylate kinase 2 ISO SMPDB SMP:00630 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00630 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO SMPDB SMP:00630 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      anti-infective drug pathway 27
        abacavir drug pathway + 0
        adefovir drug pathway + 4
        amikacin drug pathway + 0
        arbekacin drug pathway + 0
        azithromycin drug pathway + 0
        didanosine drug pathway + 0
        erythromycin drug pathway + 0
        gentamicin drug pathway + 0
        kanamycin drug pathway + 0
        lamivudine drug pathway + 18
        neviparine drug pathway + 6
        stavudine drug pathway + 0
        streptomycin drug pathway + 0
        tenofovir drug pathway + 4
        tobramycin drug pathway + 0
        zidovudine drug pathway + 0
paths to the root