AK1 (adenylate kinase 1) - Rat Genome Database

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Gene: AK1 (adenylate kinase 1) Canis lupus familiaris
Analyze
Symbol: AK1
Name: adenylate kinase 1
RGD ID: 12169940
Description: ENCODES a protein that exhibits adenylate kinase activity (ortholog); phosphotransferase activity, phosphate group as acceptor (ortholog); INVOLVED IN ADP biosynthetic process (ortholog); AMP metabolic process (ortholog); cerebellum development (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH congenital disorder of glycosylation Iu (ortholog); congenital nonspherocytic hemolytic anemia (ortholog); Congenital Nonspherocytic Hemolytic Anemia 3 (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); sarcomere (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenylate kinase isoenzyme 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,539,179 - 55,548,132 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,539,260 - 55,548,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,737,172 - 54,742,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,461,156 - 56,477,699 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,461,226 - 56,470,095 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,225,113 - 55,230,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,539,847 - 55,544,794 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,631,318 - 55,636,272 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,539,179 - 55,548,132 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,539,260 - 55,548,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,737,172 - 54,742,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,461,156 - 56,477,699 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,461,226 - 56,470,095 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,225,113 - 55,230,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,539,847 - 55,544,794 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,631,318 - 55,636,272 (+)NCBIUU_Cfam_GSD_1.0
AK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,866,480 - 127,879,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,866,486 - 127,877,675 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,628,759 - 130,641,900 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,668,580 - 129,679,843 (-)NCBINCBI36Build 36hg18NCBI36
Build 349127,708,222 - 127,719,495NCBI
Celera9101,279,601 - 101,290,850 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,246,223 - 100,257,472 (-)NCBIHuRef
CHM1_19130,780,691 - 130,791,941 (-)NCBICHM1_1
T2T-CHM13v2.09140,073,895 - 140,087,021 (-)NCBIT2T-CHM13v2.0
Ak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,511,770 - 32,525,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,511,770 - 32,525,070 (+)EnsemblGRCm39 Ensembl
GRCm38232,621,758 - 32,635,058 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,621,758 - 32,635,058 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,485,024 - 32,490,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,451,513 - 32,457,061 (+)NCBIMGSCv36mm8
Celera232,336,146 - 32,341,694 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Ak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,310,113 - 36,320,760 (+)NCBIGRCr8
mRatBN7.2315,912,431 - 15,923,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,912,485 - 15,923,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,984,611 - 18,991,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,569,617 - 27,576,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,820,734 - 25,827,945 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,652,143 - 11,659,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0316,995,977 - 17,002,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,821,482 - 19,822,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,741,850 - 19,742,913 (+)NCBI
Celera310,656,923 - 10,664,139 (+)NCBICelera
Cytogenetic Map3p11NCBI
Ak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419799,410 - 811,029 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419799,415 - 807,138 (+)NCBIChiLan1.0ChiLan1.0
AK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,476,471 - 11,486,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,478,853 - 11,488,753 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,987,348 - 98,997,252 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,657,338 - 127,678,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,657,338 - 127,678,245 (-)Ensemblpanpan1.1panPan2
Ak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,739,140 - 195,748,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,507,498 - 15,517,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,507,663 - 15,517,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,355,033 - 268,365,598 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,355,032 - 268,365,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,278,352 - 302,287,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,251,793 - 10,261,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,256,054 - 10,261,465 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,960,893 - 5,972,066 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,684,109 - 7,693,405 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,684,098 - 7,693,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AK1
107 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000031997   ⟹   ENSCAFP00000029795
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl955,543,182 - 55,548,132 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000046265   ⟹   ENSCAFP00000042516
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl955,539,260 - 55,547,952 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009435   ⟹   ENSCAFP00845007382
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl956,461,226 - 56,469,915 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009443   ⟹   ENSCAFP00845007389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl956,465,148 - 56,470,095 (+)Ensembl
RefSeq Acc Id: NM_001131047   ⟹   NP_001124519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1955,543,182 - 55,548,132 (+)NCBI
Dog10K_Boxer_Tasha954,737,172 - 54,742,120 (+)NCBI
ROS_Cfam_1.0956,465,148 - 56,470,095 (+)NCBI
UMICH_Zoey_3.1955,225,113 - 55,230,060 (+)NCBI
UNSW_CanFamBas_1.0955,539,847 - 55,544,794 (+)NCBI
UU_Cfam_GSD_1.0955,631,318 - 55,636,272 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038675028   ⟹   XP_038530956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0956,465,112 - 56,477,699 (+)NCBI
RefSeq Acc Id: XM_038675029   ⟹   XP_038530957
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0956,465,112 - 56,477,545 (+)NCBI
RefSeq Acc Id: XM_038675030   ⟹   XP_038530958
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0956,465,113 - 56,477,457 (+)NCBI
RefSeq Acc Id: XM_038675031   ⟹   XP_038530959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0956,465,113 - 56,477,535 (+)NCBI
RefSeq Acc Id: XM_038675032   ⟹   XP_038530960
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0956,461,156 - 56,469,980 (+)NCBI
RefSeq Acc Id: NP_001124519   ⟸   NM_001131047
- UniProtKB: B4YY02 (UniProtKB/TrEMBL),   A0A8C0N8N8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000029795   ⟸   ENSCAFT00000031997
Ensembl Acc Id: ENSCAFP00000042516   ⟸   ENSCAFT00000046265
RefSeq Acc Id: XP_038530960   ⟸   XM_038675032
- Peptide Label: isoform X5
- UniProtKB: A0A8C0SVP6 (UniProtKB/TrEMBL),   A0A8C0KT34 (UniProtKB/TrEMBL),   A0A8I3MQJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530956   ⟸   XM_038675028
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530957   ⟸   XM_038675029
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038530959   ⟸   XM_038675031
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038530958   ⟸   XM_038675030
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCAFP00845007389   ⟸   ENSCAFT00845009443
Ensembl Acc Id: ENSCAFP00845007382   ⟸   ENSCAFT00845009435

Promoters
RGD ID:13684829
Promoter ID:EPDNEW_C2897
Type:multiple initiation site
Name:AK1_1
Description:adenylate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1955,539,243 - 55,539,303EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020105 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011795 UniProtKB/TrEMBL
  ENSCAFG00040016357 UniProtKB/TrEMBL
  ENSCAFG00845005295 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031997.4 UniProtKB/TrEMBL
  ENSCAFT00000046265.4 UniProtKB/TrEMBL
  ENSCAFT00030021855.1 UniProtKB/TrEMBL
  ENSCAFT00030021931.1 UniProtKB/TrEMBL
  ENSCAFT00040030234.1 UniProtKB/TrEMBL
  ENSCAFT00040030262.1 UniProtKB/TrEMBL
  ENSCAFT00845009435 ENTREZGENE
  ENSCAFT00845009435.1 UniProtKB/TrEMBL
  ENSCAFT00845009443 ENTREZGENE
  ENSCAFT00845009443.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Adenylat/UMP-CMP_kin UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/TrEMBL
  AK1 UniProtKB/TrEMBL
  AK1/5 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:480712 UniProtKB/TrEMBL
NCBI Gene AK1 ENTREZGENE
PANTHER ADENYLATE KINASE ISOENZYME 1 UniProtKB/TrEMBL
  PTHR23359 UniProtKB/TrEMBL
Pfam ADK UniProtKB/TrEMBL
PRINTS ADENYLTKNASE UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0KT34 ENTREZGENE
  A0A8C0N8N8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SVP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQJ7 ENTREZGENE, UniProtKB/TrEMBL
  B4YY02 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37745 ENTREZGENE