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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:non-small cell lung carcinoma pathway
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Accession:PW:0000705 term browser browse the term
Definition:Non-small cell lung carcinoma groups together several non-small cell lung carcinomas. The main types are represented by squamous cell, adeno- and large-cell carcinoma. Alterations in Ras and epidermal growth factor signaling, among others, have been implicated in the condition.
Synonyms:exact_synonym: non-small cell lung cancer pathway
 related_synonym: KEGG:05223;   NSCLC pathway;   non-small cell lung neoplasm pathway
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non-small cell lung carcinoma pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:21277552 RGD:5133243 NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:20951313 PMID:21277552 RGD:5133242 RGD:5133243 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20519133 PMID:20951313 RGD:5133241 RGD:5133242 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:21277552 RGD:5133243 NCBI chrNW_004624795:3,373,313...3,391,509
Ensembl chrNW_004624795:3,373,000...3,391,602 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:20951313 RGD:5133242 NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242 RGD:5133243 NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:20519133 PMID:20951313 PMID:21277552 RGD:5133241 RGD:5133242 RGD:5133243 NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO RGD PMID:20951313 PMID:21277552 RGD:5133242 RGD:5133243 NCBI chrNW_004624730:56,895,065...56,970,563
Ensembl chrNW_004624730:56,938,215...56,966,137 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:20951313 RGD:5133242 NCBI chrNW_004624791:13,975,235...14,056,900 JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:20951313 RGD:5133242 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    disease pathway 670
      cancer pathway 55
        thoracic cancer pathway 10
          respiratory tract cancer pathway 10
            lung cancer pathway 10
              non-small cell lung carcinoma pathway 10
paths to the root