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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2
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Accession:PW:0000586 term browser browse the term
Definition:Orexin/hypocretin signaling through receptor 2 couples to Galphaq and the inhibitory Galphai classes of G proteins. Orexin/hypocretin receptor 2 binds both orexin A and B derived from the prepro-orexin precursor.


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orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai1 G protein subunit alpha i1 IMP RGD PMID:12890892 RGD:1642020 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnaq G protein subunit alpha q IMP RGD PMID:12890892 RGD:1642020 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Hcrt hypocretin neuropeptide precursor IDA RGD PMID:12890892 RGD:1642020 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hcrtr2 hypocretin receptor 2 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2635
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          orexin/hypocretin signaling pathway 6
            orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2 4
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