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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:somatostatin signaling pathway
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Accession:PW:0000579 term browser browse the term
Definition:Somatostatin signaling through its receptors regulates processes such as proliferation, secretion and motility via inhibition of growth hormone and factor. The potential anti-tumor activity of somatostatin has led to the development and clinical use of its analogs.
Synonyms:related_synonym: SRIF;   somatotropin release inhibitory factor


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somatostatin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:23073237 RGD:13792788 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:17021051 RGD:1641809 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO RGD PMID:17021051 RGD:1641809 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J ISO RGD PMID:17021051 RGD:1641809 NCBI chr11:47,941,134...48,130,538
Ensembl chr11:48,613,761...48,670,494 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:17021051 RGD:1641809 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G SST somatostatin ISO RGD PMID:17021051 RGD:1641809 NCBI chr 3:184,695,561...184,697,091
Ensembl chr 3:193,155,363...193,158,337 		JBrowse link
G SSTR1 somatostatin receptor 1 ISO RGD PMID:17021051 RGD:1641809 NCBI chr14:18,968,969...18,973,560
Ensembl chr14:37,329,309...37,330,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    signaling pathway 1930
      hormone signaling pathway 380
        peptide and protein hormone signaling pathway 273
          somatostatin signaling pathway 7
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