PTPRJ (protein tyrosine phosphatase receptor type J) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PTPRJ (protein tyrosine phosphatase receptor type J) Pan paniscus
Analyze
Symbol: PTPRJ
Name: protein tyrosine phosphatase receptor type J
RGD ID: 11980872
Description: ENCODES a protein that exhibits beta-catenin binding (inferred); cadherin binding (inferred); delta-catenin binding (inferred); INVOLVED IN heart development (ortholog); obsolete calcium-mediated signaling using intracellular calcium source (ortholog); oligodendrocyte differentiation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; platelet-derived growth factor signaling pathway; somatostatin signaling pathway; ASSOCIATED WITH colon carcinoma (ortholog); colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (inferred); cell-cell junction (inferred); immunological synapse (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-type tyrosine-protein phosphatase eta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2950,196,084 - 50,386,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,215,619 - 50,406,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,941,134 - 48,130,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,518,844 - 48,672,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,613,761 - 48,670,494 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IEA)
blood coagulation  (IEA)
glucose homeostasis  (IEA)
heart development  (IEA,ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of epidermal growth factor receptor signaling pathway  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA)
negative regulation of T cell receptor signaling pathway  (IEA)
negative regulation of vascular permeability  (IEA)
obsolete calcium-mediated signaling using intracellular calcium source  (ISO)
oligodendrocyte differentiation  (IEA,ISO)
platelet formation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IEA)
positive chemotaxis  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of Fc receptor mediated stimulatory signaling pathway  (IEA)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of platelet activation  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
regulation of cell adhesion  (IEA)
vasculogenesis  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPRJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2950,196,084 - 50,386,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,215,619 - 50,406,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,941,134 - 48,130,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,518,844 - 48,672,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,613,761 - 48,670,494 (+)Ensemblpanpan1.1panPan2
PTPRJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,980,559 - 48,170,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,980,425 - 48,170,839 (+)EnsemblGRCh38hg38GRCh38
GRCh371148,002,111 - 48,192,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,958,686 - 48,148,970 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,958,688 - 48,146,246NCBI
Celera1148,154,504 - 48,344,533 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,683,384 - 47,903,543 (+)NCBIHuRef
CHM1_11148,001,881 - 48,191,974 (+)NCBICHM1_1
T2T-CHM13v2.01148,150,119 - 48,340,376 (+)NCBIT2T-CHM13v2.0
Ptprj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,260,100 - 90,411,102 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,260,098 - 90,410,939 (-)EnsemblGRCm39 Ensembl
GRCm38290,429,756 - 90,580,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl290,429,754 - 90,580,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,269,913 - 90,420,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,233,731 - 90,381,407 (-)NCBIMGSCv36mm8
Celera291,810,313 - 91,967,158 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.19NCBI
Ptprj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,861,785 - 97,017,702 (-)NCBIGRCr8
mRatBN7.2376,405,917 - 76,561,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,405,927 - 76,562,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx379,890,269 - 80,046,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,488,786 - 88,644,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,341,245 - 86,497,188 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,233,519 - 79,390,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,233,525 - 79,390,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0385,947,682 - 86,099,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4374,796,764 - 74,935,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1374,693,135 - 74,831,912 (-)NCBI
Celera375,621,921 - 75,777,388 (-)NCBICelera
Cytogenetic Map3q24NCBI
Ptprj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422399,357 - 443,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955422396,266 - 438,792 (-)NCBIChiLan1.0ChiLan1.0
PTPRJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11841,586,262 - 41,635,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,426 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBIUU_Cfam_GSD_1.0
Ptprj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,050,113 - 19,123,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,165,304 - 1,211,817 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,161,764 - 1,234,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl214,548,428 - 14,724,474 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1214,548,489 - 14,724,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2215,632,255 - 16,007,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,137,896 - 17,328,836 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,135,907 - 17,328,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038114,433,977 - 114,653,560 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624767945,553 - 1,051,138 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624767942,786 - 1,051,112 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000033246   ⟹   ENSPPAP00000010594
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1148,613,761 - 48,634,775 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000033270   ⟹   ENSPPAP00000010618
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1148,613,982 - 48,670,494 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000033273   ⟹   ENSPPAP00000010621
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1148,614,012 - 48,635,378 (+)Ensembl
RefSeq Acc Id: XM_034932625   ⟹   XP_034788516
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2950,196,104 - 50,386,550 (+)NCBI
NHGRI_mPanPan11150,215,713 - 50,406,485 (+)NCBI
Mhudiblu_PPA_v01147,941,136 - 48,130,538 (+)NCBI
RefSeq Acc Id: XM_034932626   ⟹   XP_034788517
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2950,196,084 - 50,347,394 (+)NCBI
NHGRI_mPanPan11150,215,619 - 50,367,299 (+)NCBI
Mhudiblu_PPA_v01147,941,134 - 48,093,539 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034788516 (Get FASTA)   NCBI Sequence Viewer  
  XP_034788517 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010594.1
  ENSPPAP00000010618.1
  ENSPPAP00000010621.1
Reference Protein Sequences
RefSeq Acc Id: XP_034788517   ⟸   XM_034932626
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034788516   ⟸   XM_034932625
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000010594   ⟸   ENSPPAT00000033246
RefSeq Acc Id: ENSPPAP00000010621   ⟸   ENSPPAT00000033273
RefSeq Acc Id: ENSPPAP00000010618   ⟸   ENSPPAT00000033270
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028501 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033246.1 UniProtKB/TrEMBL
  ENSPPAT00000033270.1 UniProtKB/TrEMBL
  ENSPPAT00000033273.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPRJ ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H UniProtKB/TrEMBL
  SUBSTRATE-ADHESION MOLECULE UniProtKB/TrEMBL
  TENASCIN UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  PTP_tm UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A2R9A039_PANPA UniProtKB/TrEMBL
  A0A2R9A1A0_PANPA UniProtKB/TrEMBL
  A0A2R9A4C8_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPRJ  protein tyrosine phosphatase receptor type J    protein tyrosine phosphatase, receptor type J  Symbol and/or name change 5135510 APPROVED