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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal NK cell physiology
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Accession:MP:0010766 term browser browse the term
Definition:any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
Synonyms:exact_synonym: NK cell dysfunction;   abnormal natural killer cell physiology;   dysfunctional NK cells;   natural killer cell dysfunction
 alt_id: MP:0005069
 xref: CL:0000623;   FMA:63147;   FMA:83601


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impaired natural killer cell mediated cytotoxicity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5403
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal innate immunity 24
          abnormal NK cell physiology 5
            abnormal natural killer cell mediated cytotoxicity + 5
            abnormal uterine NK cell physiology 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5403
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal adaptive immunity 60
          abnormal leukocyte physiology 56
            abnormal lymphocyte physiology 49
              abnormal NK cell physiology 5
                abnormal natural killer cell mediated cytotoxicity + 5
                abnormal uterine NK cell physiology 0
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