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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Fava bean-induced hemolytic anemia
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Accession:HP:0004814 term browser browse the term
Definition:A kind of hemolytic anemia that is induced by the ingestion of fava beans.
Comment:Persons with glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to fava bean-induced hemolytic anemia because of the oxidative stress induced by compunds in Fava beans (thought to be vicine and isouramil). The same underlying defect can make affected persons susceptible to hemolysis induced by a number of mediciations.
Synonyms:exact_synonym: Fava bean-induced hemolytic anaemia;   Hemolytic anaemia following ingestion of fava beans;   Hemolytic anemia following ingestion of fava beans
 xref: UMLS:C4021648


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Fava bean-induced hemolytic anemia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASK calcium/calmodulin dependent serine protein kinase IAGP HPO OMIM:300908 NCBI chr  X:41,514,934...41,923,554
Ensembl chr  X:41,514,934...41,923,554 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase IAGP HPO OMIM:300908 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GSR glutathione-disulfide reductase IAGP HPO OMIM:618660 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
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Term Annotations click to browse term
  Human phenotype 21568
    Phenotypic abnormality 21558
      Abnormality of blood and blood-forming tissues 2649
        Abnormal erythrocyte morphology 989
          Anemia 915
            Anemia due to reduced life span of red cells 181
              Hemolytic anemia 178
                Fava bean-induced hemolytic anemia 3
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