large conductance calcium-activated potassium channel activity - Ontology Report

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Term:	large conductance calcium-activated potassium channel activity	go back to main search page
Accession:	GO:0060072	browse the term
Definition:	Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
Synonyms:	exact_synonym:	BK KCa channel activity; BK calcium-activated potassium channel activity; large conductance KCa channel activity
	related_synonym:	BK channel activity
	alt_id:	GO:0022895

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Kcnma1

potassium calcium-activated channel subfamily M alpha 1

enables

(PMID:7993625)
(PMID:15703204)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118
MGI:3053849 (MGI:5560378|PMID:24602615), (PMID:12388098), (PMID:16873365)

GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:5560378, RGD:7205477

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

potassium calcium-activated channel subfamily U member 1

NOT|enables

GO_REF:0000033

GO_REF:0000033

NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465

Term paths to the root

Path 1
Term	Annotations
molecular_function	21010
transporter activity	1259
transmembrane transporter activity	1163
monoatomic ion transmembrane transporter activity	769
monoatomic cation transmembrane transporter activity	648
monoatomic cation channel activity	347
potassium channel activity	128
calcium-activated potassium channel activity	12
large conductance calcium-activated potassium channel activity	2
Path 2
Term	Annotations
molecular_function	21010
transporter activity	1259
transmembrane transporter activity	1163
passive transmembrane transporter activity	519
channel activity	519
gated channel activity	332
ligand-gated channel activity	187
ligand-gated monoatomic ion channel activity	183
ligand-gated monoatomic cation channel activity	129
calcium-activated cation channel activity	26
calcium-activated potassium channel activity	12
large conductance calcium-activated potassium channel activity	2

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