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ONTOLOGY REPORT - ANNOTATIONS

Term:ketone body biosynthetic process
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Accession:GO:0046951 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms:exact_synonym: ketone body anabolism;   ketone body biosynthesis;   ketone body formation;   ketone body synthesis


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ketone body biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase involved_in IDA
ISO
IEA
IBA		 (PMID:22847177), (PMID:22865860), (PMID:9200711)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:9200711 PMID:22847177 PMID:22865860 PMID:2573547 GO_REF:0000033 GO_REF:0000107, RGD:1599519 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068 		JBrowse link
G Hmgcll1 3-hydroxy-3-methylglutaryl-CoA lyase like 1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:22847177), (PMID:22865860)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:22847177 PMID:22865860 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:76,757,301...76,887,300
Ensembl chr 8:76,757,497...76,886,816 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in TAS
IEP
ISO		 (PMID:23751782) RGD PMID:23751782 PMID:8097464 PMID:12399220 RGD:728598, RGD:2326121 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 acts_upstream_of_or_within ISO MGI:3757682 (PMID:16618416) RGD PMID:16618416 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20052
    cellular process 19130
      metabolic process 11925
        biosynthetic process 8446
          small molecule biosynthetic process 624
            ketone body biosynthetic process 4
              acetoacetic acid biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 20052
    cellular process 19130
      metabolic process 11925
        primary metabolic process 10561
          lipid metabolic process 1446
            fatty acid derivative metabolic process 59
              fatty acid derivative biosynthetic process 26
                ketone body biosynthetic process 4
                  acetoacetic acid biosynthetic process 0
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