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ONTOLOGY REPORT - ANNOTATIONS


Term:ketone body biosynthetic process
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Accession:GO:0046951 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms:exact_synonym: ketone body anabolism;   ketone body biosynthesis;   ketone body formation;   ketone body synthesis


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ketone body biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase involved_in IDA
IBA
ISO
PMID:21873635
(PMID:22847177), (PMID:22865860), (PMID:9200711)
RGD PMID:9200711 PMID:22847177 PMID:22865860 PMID:2573547 PMID:21873635 RGD:1599519, RGD:13792537 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068
JBrowse link
G Hmgcll1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:22847177), (PMID:22865860)
PMID:21873635
UniProt
RGD
PMID:22847177 PMID:22865860 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:76,757,301...76,887,300
Ensembl chr 8:76,757,497...76,886,816
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in TAS
ISO
IEP
(PMID:23751782) RGD PMID:23751782 PMID:8097464 PMID:12399220 RGD:728598, RGD:2326121 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Slc27a5 solute carrier family 27 member 5 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3757682 (MGI:3722951|PMID:16618416)
RGD PMID:16618416 PMID:21873635 MGI:3722951, RGD:13792537 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      biosynthetic process 6071
        cellular biosynthetic process 5913
          ketone body biosynthetic process 4
            acetoacetic acid biosynthetic process 0
            acetone biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cellular metabolic process 10717
        generation of precursor metabolites and energy 502
          ketone body metabolic process 10
            ketone body biosynthetic process 4
              acetoacetic acid biosynthetic process 0
              acetone biosynthetic process 0
paths to the root