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ONTOLOGY REPORT - ANNOTATIONS

Term:leucine-tRNA ligase activity
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Accession:GO:0004823 term browser browse the term
Definition:Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu).
Synonyms:exact_synonym: leucyl-tRNA synthetase activity
 related_synonym: leucine translase activity;   leucine-tRNA synthetase activity;   leucine:tRNALeu ligase (AMP-forming);   leucyl-transfer RNA synthetase activity;   leucyl-transfer ribonucleate synthetase activity;   leucyl-transfer ribonucleic acid synthetase activity
 xref: EC:6.1.1.4;   KEGG_REACTION:R03657;   MetaCyc:LEUCINE--TRNA-LIGASE-RXN;   RHEA:11688;   reactome:R-HSA-379974 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate";   reactome:R-HSA-380200 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate"


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leucine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LARS1 leucyl-tRNA synthetase 1 enables IEA InterPro
TreeGrafter
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:141,562,798...141,631,388
Ensembl chr 5:147,578,042...147,646,834 		JBrowse link
G LARS2 leucyl-tRNA synthetase 2, mitochondrial enables IEA Ensembl
UniProt
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:45,296,129...45,455,836
Ensembl chr 3:46,405,636...46,564,994 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      ligase activity 167
        ligase activity, forming carbon-oxygen bonds 43
          aminoacyl-tRNA ligase activity 43
            leucine-tRNA ligase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on RNA 366
          catalytic activity, acting on a tRNA 132
            aminoacyl-tRNA ligase activity 43
              leucine-tRNA ligase activity 2
paths to the root