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ONTOLOGY REPORT - ANNOTATIONS

Term:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
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Accession:GO:0003863 term browser browse the term
Definition:Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.
Synonyms:narrow_synonym: alpha-ketoacid dehydrogenase activity
 related_synonym: 2-oxoisocaproate dehydrogenase activity;   2-oxoisovalerate (lipoate) dehydrogenase activity;   3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity;   3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating);   3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity;   BCKDH activity;   BCOAD activity;   alpha-keto-alpha-methylvalerate dehydrogenase activity;   alpha-ketoisocaproate dehydrogenase activity;   alpha-ketoisocaproic dehydrogenase activity;   alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity;   alpha-ketoisovalerate dehydrogenase activity;   alpha-oxoisocaproate dehydrogenase activity;   branched chain keto acid dehydrogenase activity;   branched-chain (-2-oxoacid) dehydrogenase (BCD) activity;   branched-chain 2-keto acid dehydrogenase activity;   branched-chain 2-oxo acid dehydrogenase activity;   branched-chain alpha-keto acid dehydrogenase activity;   branched-chain alpha-oxo acid dehydrogenase activity;   branched-chain ketoacid dehydrogenase activity
 alt_id: GO:0003826
 xref: EC:1.2.4.4;   MetaCyc:1.2.4.4-RXN;   RHEA:13457

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3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha enables
contributes_to		 ISO (PMID:7883996)
(PMID:10745006), (PMID:9582350)		 HGNC-UCL
UniProt		 PMID:7883996 PMID:9582350 PMID:10745006 NCBI chrNW_004955555:334,253...357,417
Ensembl chrNW_004955555:333,642...358,799 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta contributes_to
enables		 ISO (PMID:2022752)
(PMID:9611264)
(PMID:10745006), (PMID:9582350)		 HGNC
MGI
UniProt		 PMID:2022752 PMID:9582350 PMID:9611264 PMID:10745006 NCBI chrNW_004955411:8,427,875...8,626,564
Ensembl chrNW_004955411:8,437,548...8,628,363 		JBrowse link
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  molecular_function 14225
    catalytic activity 3723
      oxidoreductase activity 472
        oxidoreductase activity, acting on the aldehyde or oxo group of donors 33
          oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 6
            3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 2
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