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ONTOLOGY REPORT - ANNOTATIONS

Term:pH-gated monoatomic ion channel activity
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Accession:GO:0160128 term browser browse the term
Definition:Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).
Comment:While the term suggest this activity may be proton-gated, the mechanism of pH-gating for transporters is by protonation of specific residues in the protein, and not by H+ binding.
Synonyms:related_synonym: acid-sensing ion channel activity;   proton-gated ion channel activity
 xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol"


show annotations for term's descendants           Sort by:
pH-gated monoatomic ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIC1 acid sensing ion channel subunit 1 enables
NOT|enables		 ISS
IDA
IEA		 (PMID:21036899), (PMID:22760635) UniProt
Ensembl		 PMID:21036899 PMID:22760635 GO_REF:0000024 GO_REF:0000107 NCBI chr12:50,057,596...50,083,622
Ensembl chr12:50,057,548...50,083,611 		JBrowse link
G ASIC3 acid sensing ion channel subunit 3 enables IDA (PMID:9744806) UniProt PMID:9744806 NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756 		JBrowse link
G PKD1L3 polycystin 1 like 3, transient receptor potential channel interacting enables IDA (PMID:19464260), (PMID:22420714), (PMID:23212381) UniProt PMID:19464260 PMID:22420714 PMID:23212381 NCBI chr16:71,929,538...72,000,402
Ensembl chr16:71,929,538...72,000,402 		JBrowse link
G PKD2L1 polycystin 2 like 1, transient receptor potential cation channel enables ISS
IEA
IDA		 (PMID:23212381) UniProt
Ensembl		 PMID:23212381 GO_REF:0000024 GO_REF:0000107 NCBI chr10:100,288,149...100,330,228
Ensembl chr10:100,288,149...100,330,264 		JBrowse link
G ZACN zinc activated ion channel enables IDA (PMID:26872532) UniProt PMID:26872532 NCBI chr17:76,079,182...76,082,806
Ensembl chr17:76,071,961...76,083,666 		JBrowse link
pH-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIC3 acid sensing ion channel subunit 3 enables ISO PMID:11120882 UniProt PMID:11120882 RGD:596936209 NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756 		JBrowse link
pH-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP6 aquaporin 6 enables ISS UniProt GO_REF:0000024 NCBI chr12:49,972,947...49,977,139
Ensembl chr12:49,967,194...49,977,139 		JBrowse link
G PACC1 proton activated chloride channel 1 enables IEA
IDA		 (PMID:31023925), (PMID:31318332) Ensembl
UniProt		 PMID:31023925 PMID:31318332 GO_REF:0000107 NCBI chr 1:212,363,928...212,414,886
Ensembl chr 1:212,363,928...212,414,901 		JBrowse link
pH-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIC2 acid sensing ion channel subunit 2 enables IDA (PMID:10842183) UniProt PMID:10842183 NCBI chr17:33,013,087...34,156,768
Ensembl chr17:33,013,087...34,174,964 		JBrowse link
G ASIC3 acid sensing ion channel subunit 3 enables IDA (PMID:10842183), (PMID:9744806), (PMID:9886053) UniProt PMID:9744806 PMID:9886053 PMID:10842183 NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756 		JBrowse link
G ASIC4 acid sensing ion channel subunit family member 4 NOT|enables ISO PMID:10923674
PMID:10852210		 UniProt PMID:10852210 PMID:10923674 RGD:596936205 RGD:632227 NCBI chr 2:219,507,093...219,538,772
Ensembl chr 2:219,514,170...219,538,772 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19684
    transporter activity 1302
      transmembrane transporter activity 1180
        monoatomic ion transmembrane transporter activity 797
          monoatomic ion channel activity 468
            ligand-gated monoatomic ion channel activity 195
              pH-gated monoatomic ion channel activity 9
                pH-gated calcium channel activity 1
                pH-gated chloride channel activity 2
                pH-gated sodium channel activity 3
Path 2
Term Annotations click to browse term
  molecular_function 19684
    transporter activity 1302
      transmembrane transporter activity 1180
        passive transmembrane transporter activity 533
          channel activity 533
            gated channel activity 340
              ligand-gated channel activity 200
                ligand-gated monoatomic ion channel activity 195
                  pH-gated monoatomic ion channel activity 9
                    pH-gated calcium channel activity 1
                    pH-gated chloride channel activity 2
                    pH-gated sodium channel activity 3
paths to the root