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ONTOLOGY REPORT - ANNOTATIONS

Term:promoter-enhancer loop anchoring activity
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Accession:GO:0140585 term browser browse the term
Definition:Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop.
Comment:Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element.


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promoter-enhancer loop anchoring activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahdc1 AT hook, DNA binding motif, containing 1 enables ISO (PMID:35585237) RGD PMID:35585237 NCBI chr 5:145,228,228...145,294,170
Ensembl chr 5:145,228,227...145,294,145 		JBrowse link
G Msl2 MSL complex subunit 2 enables ISO (PMID:38030723) RGD PMID:38030723 NCBI chr 8:101,676,605...101,702,818
Ensembl chr 8:101,676,765...101,763,833 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 enables ISO (PMID:31361039) RGD PMID:31361039 NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 enables ISO (PMID:23637611) RGD PMID:23637611 NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    molecular adaptor activity 1225
      DNA-DNA tethering activity 5
        chromatin loop anchoring activity 5
          promoter-enhancer loop anchoring activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20626
    binding 17717
      organic cyclic compound binding 6134
        nucleic acid binding 3844
          DNA binding 2276
            double-stranded DNA binding 1452
              DNA-DNA tethering activity 5
                chromatin loop anchoring activity 5
                  promoter-enhancer loop anchoring activity 4
paths to the root