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ONTOLOGY REPORT - ANNOTATIONS

Term:class I DNA-(apurinic or apyrimidinic site) endonuclease activity
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Accession:GO:0140078 term browser browse the term
Definition:Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
Comment:Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Synonyms:exact_synonym: AP site-DNA 5'-phosphomonoester-lyase activity;   DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity;   DNA-(apurinic or apyrimidinic site) lyase activity;   class I DNA-(apurinic or apyrimidinic site) lyase activity
 related_synonym: AP endonuclease class I activity;   AP lyase activity
 xref: EC:4.2.99.18;   MetaCyc:4.2.99.18-RXN;   RHEA:66592;   Wikipedia:AP_endonuclease


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class I DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh1 alkB homolog 1, histone H2A dioxygenase enables ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:87,474,847...87,490,609
Ensembl chr12:87,472,610...87,490,787 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Neil2 nei like 2 (E. coli) enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr14:63,419,888...63,431,604
Ensembl chr14:63,419,892...63,431,305 		JBrowse link
G Neil3 nei like 3 (E. coli) enables IEA RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 8:54,039,902...54,092,100
Ensembl chr 8:54,039,902...54,092,100 		JBrowse link
G Nthl1 nth (endonuclease III)-like 1 (E.coli) enables IEA
ISO		 UniProt
RHEA
GO_Central		 GO_REF:0000003 GO_REF:0000116 GO_REF:0000119 NCBI chr17:24,851,656...24,857,812
Ensembl chr17:24,851,654...24,857,811 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Polb polymerase (DNA directed), beta enables IEA
ISO		 RHEA
GO_Central		 GO_REF:0000116 GO_REF:0000119 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451 		JBrowse link
G Rps3 ribosomal protein S3 enables IEA RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28796
    catalytic activity 5725
      lyase activity 205
        carbon-oxygen lyase activity 79
          class I DNA-(apurinic or apyrimidinic site) endonuclease activity 8
Path 2
Term Annotations click to browse term
  molecular_function 28796
    catalytic activity 5725
      catalytic activity, acting on a nucleic acid 647
        catalytic activity, acting on DNA 326
          DNA-(apurinic or apyrimidinic site) endonuclease activity 15
            class I DNA-(apurinic or apyrimidinic site) endonuclease activity 8
paths to the root