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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA NAD-cap (NMN-forming) hydrolase activity
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Accession:GO:0110153 term browser browse the term
Definition:Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+.
Comment:This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.
Synonyms:xref: RHEA:60876


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RNA NAD-cap (NMN-forming) hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT12 nudix hydrolase 12 enables ISO (PMID:31101919) UniProt PMID:31101919 NCBI chr 2:109,044,946...109,059,721
Ensembl chr 2:109,045,592...109,059,616 		JBrowse link
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Term Annotations click to browse term
  molecular_function 19428
    catalytic activity 5613
      catalytic activity, acting on a nucleic acid 608
        catalytic activity, acting on RNA 378
          RNA NAD-cap (NMN-forming) hydrolase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 19428
    catalytic activity 5613
      hydrolase activity 2375
        hydrolase activity, acting on acid anhydrides 713
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 712
            pyrophosphatase activity 706
              RNA NAD-cap (NMN-forming) hydrolase activity 1
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