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ONTOLOGY REPORT - ANNOTATIONS

Term:prostaglandin-E synthase activity
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Accession:GO:0050220 term browser browse the term
Definition:Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).
Synonyms:related_synonym: (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity;   PGE isomerase activity;   PGE2 isomerase activity;   PGH-PGE isomerase activity;   Prostaglandin-H(2) E-isomerase activity;   endoperoxide isomerase activity;   prostaglandin H-E isomerase activity;   prostaglandin R-prostaglandin E isomerase activity;   prostaglandin endoperoxide E isomerase activity;   prostaglandin endoperoxide E2 isomerase activity;   prostaglandin-H2 E-isomerase activity
 xref: EC:5.3.99.3;   KEGG_REACTION:R02265;   MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN;   RHEA:12893;   reactome:R-HSA-2161660 "PGH2 is isomerised to PGE2 by PTGES";   reactome:R-HSA-265295 "Prostaglandin E synthase isomerizes PGH2 to PGE2"


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prostaglandin-E synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptges prostaglandin E synthase enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:18682561)		 GO_Central
RGD		 PMID:18682561 PMID:11067848 GO_REF:0000033, RGD:67929 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 enables ISO
IBA		 (PMID:12804604)
GO_REF:0000033		 RGD
GO_Central		 PMID:12804604 GO_REF:0000033 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688 		JBrowse link
G Ptges3 prostaglandin E synthase 3 enables IDA
ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:10922363)
GO_REF:0000104
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:10922363 PMID:10922363 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104, RGD:5688071 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptges3l1 prostaglandin E synthase 3-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:42,215,200...42,224,472
Ensembl chr  X:42,214,756...42,225,047 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 20811
    catalytic activity 6119
      isomerase activity 220
        intramolecular oxidoreductase activity 76
          prostaglandin-E synthase activity 4
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