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ONTOLOGY REPORT - ANNOTATIONS

Term:lipopolysaccharide receptor complex
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Accession:GO:0046696 term browser browse the term
Definition:A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.
Comment:Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
Synonyms:exact_synonym: LPS receptor complex


show annotations for term's descendants           Sort by:
lipopolysaccharide receptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule part_of TAS
ISO
ISS
IBA		 (PMID:11274165)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:11274165 PMID:12218159 GO_REF:0000024 GO_REF:0000033, RGD:727423 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 part_of ISO (PMID:17164250) RGD PMID:17164250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ly96 lymphocyte antigen 96 part_of ISO (PMID:11274165), (PMID:19252480)
(MGI:5645195|PMID:24380872)		 RGD PMID:11274165 PMID:19252480 PMID:24380872 MGI:5645195 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386 		JBrowse link
G Tlr4 toll-like receptor 4 part_of IEA
ISO
ISS		 GO_REF:0000107
(PMID:11274165), (PMID:19252480)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:11274165 PMID:19252480 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tril TLR4 interactor with leucine-rich repeats part_of ISO
IBA		 (PMID:19710467)
GO_REF:0000033		 RGD
GO_Central		 PMID:19710467 GO_REF:0000033 NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20811
    protein-containing complex 6431
      receptor complex 445
        lipopolysaccharide receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20811
    cellular anatomical entity 20571
      membrane 10305
        membrane protein complex 1369
          lipopolysaccharide receptor complex 5
paths to the root