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ONTOLOGY REPORT - ANNOTATIONS

Term:heparanase activity
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Accession:GO:0030305 term browser browse the term
Definition:Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.
Synonyms:related_synonym: heparinase activity
 xref: reactome:R-HSA-1667005 "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)"


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heparanase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPSE heparanase contributes_to
enables		 ISO
IEA		 (PMID:12927802) UniProt
RGD
Ensembl		 PMID:12077130 PMID:12927802 GO_REF:0000107 RGD:632901 NCBI chr 8:135,082,199...135,120,887
Ensembl chr 8:135,097,725...135,120,887 		JBrowse link
G HPSE2 heparanase 2 (inactive) NOT|enables ISO (PMID:20576607) UniProt PMID:20576607 NCBI chr14:109,764,511...110,469,064
Ensembl chr14:109,764,170...110,469,141 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18681
    catalytic activity 5611
      hydrolase activity 2376
        hydrolase activity, acting on glycosyl bonds 132
          hydrolase activity, hydrolyzing O-glycosyl compounds 105
            heparanase activity 2
paths to the root