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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of endopeptidase activity
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Accession:GO:0010951 term browser browse the term
Definition:Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

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negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101959212 alpha-2-macroglobulin ISO RGD PMID:19240864 RGD:7411612 NCBI chrNW_004936870:424,832...468,303
Ensembl chrNW_004936870:424,951...468,167 		JBrowse link
G Renbp renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chrNW_004936809:817,392...823,926
Ensembl chrNW_004936809:817,355...823,941 		JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:10717410 RGD:8547889 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chrNW_004936599:2,437,061...2,456,141
Ensembl chrNW_004936599:2,437,032...2,456,147 		JBrowse link
G LOC101966195 huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chrNW_004936477:20,443,101...20,577,167
Ensembl chrNW_004936477:20,443,113...20,577,071
Ensembl chrNW_004936477:20,443,113...20,577,071 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chrNW_004936661:2,652,568...2,694,039
Ensembl chrNW_004936661:2,652,566...2,694,086 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520 		JBrowse link
G Ep300 E1A binding protein p300 ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138 		JBrowse link
G Gpi glucose-6-phosphate isomerase ISO RGD PMID:12615053 RGD:1600634 NCBI chrNW_004936570:1,582,120...1,608,537
Ensembl chrNW_004936570:1,579,372...1,608,788 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chrNW_004936475:9,091,115...9,102,101
Ensembl chrNW_004936475:9,091,176...9,102,109 		JBrowse link
G Hnf1a HNF1 homeobox A ISO RGD PMID:21874357 RGD:150540304 NCBI chrNW_004936668:62,103...81,549
Ensembl chrNW_004936668:67,535...81,505 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 ISO reduced cleavage of Casp8 and Casp9 in brain following hypoxic/ischemic injury RGD PMID:16397188 RGD:1626654 NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G LOC101965545 NADPH--cytochrome P450 reductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chrNW_004936543:2,275,981...2,327,931
Ensembl chrNW_004936543:2,274,059...2,328,008 		JBrowse link
G Mdm2 MDM2 proto-oncogene ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Ptma prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chrNW_004936525:5,253,723...5,258,300 JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink1 serine peptidase inhibitor Kazal type 1 ISO RGD PMID:12771515 RGD:724699 NCBI chrNW_004936504:6,975,044...6,981,304
Ensembl chrNW_004936504:6,975,044...6,981,304 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15975
    metabolic process 9645
      primary metabolic process 8435
        protein metabolic process 3740
          proteolysis 1351
            negative regulation of proteolysis 138
              negative regulation of peptidase activity 18
                negative regulation of endopeptidase activity 18
                  negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 0
                  negative regulation of cysteine-type endopeptidase activity + 14
                  negative regulation of metalloendopeptidase activity + 0
                  negative regulation of serine-type endopeptidase activity 1
Path 2
Term Annotations click to browse term
  biological_process 15975
    metabolic process 9645
      organic substance metabolic process 9219
        macromolecule metabolic process 7690
          protein metabolic process 3740
            proteolysis 1351
              regulation of proteolysis 390
                negative regulation of proteolysis 138
                  negative regulation of peptidase activity 18
                    negative regulation of endopeptidase activity 18
                      negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 0
                      negative regulation of cysteine-type endopeptidase activity + 14
                      negative regulation of metalloendopeptidase activity + 0
                      negative regulation of serine-type endopeptidase activity 1
paths to the root