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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidized purine nucleobase lesion DNA N-glycosylase activity
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Accession:GO:0008534 term browser browse the term
Definition:Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
Comment:Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
Synonyms:exact_synonym: oxidized purine base lesion DNA N-glycosylase activity
 broad_synonym: 8-oxoguanine DNA glycosylase activity;   DNA glycosylase/AP-lyase activity;   DNA glycosylase/beta-lyase activity;   bifunctional DNA glycosylase activity
 related_synonym: 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity;   2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity;   DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing];   DNA-formamidopyrimidine glycosylase activity;   Fapy-DNA glycosylase activity;   Fpg protein;   deoxyribonucleate glycosidase activity;   purine-specific oxidized base lesion DNA N-glycosylase activity
 alt_id: GO:0003907
 xref: EC:3.2.2.23;   MetaCyc:3.2.2.23-RXN;   Reactome:R-HSA-110243 "Excision of 8-oxoguanine by OGG1 glycosylase";   Reactome:R-HSA-110244 "Excision of FapyG by OGG1 glycosylase";   reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase"


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oxidized purine nucleobase lesion DNA N-glycosylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OGG1 8-oxoguanine DNA glycosylase enables ISO
IEA		 RGD
InterPro		 PMID:9801319 GO_REF:0000002 RGD:729091 NCBI chr13:66,038,669...66,045,478 JBrowse link
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MUTYH mutY DNA glycosylase enables IBA GO_Central GO_REF:0000033 NCBI chr 6:166,002,853...166,012,191
Ensembl chr 6:166,003,351...166,012,190 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr13:66,038,669...66,045,478 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18681
    catalytic activity 5611
      catalytic activity, acting on a nucleic acid 610
        catalytic activity, acting on DNA 245
          DNA N-glycosylase activity 13
            oxidized base lesion DNA N-glycosylase activity 4
              oxidized purine nucleobase lesion DNA N-glycosylase activity 2
                8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 18681
    catalytic activity 5611
      hydrolase activity 2376
        hydrolase activity, acting on glycosyl bonds 132
          hydrolase activity, hydrolyzing N-glycosyl compounds 28
            DNA N-glycosylase activity 13
              oxidized base lesion DNA N-glycosylase activity 4
                oxidized purine nucleobase lesion DNA N-glycosylase activity 2
                  8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2
paths to the root