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ONTOLOGY REPORT - ANNOTATIONS

Term:calcium, potassium:sodium antiporter activity
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Accession:GO:0008273 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
Synonyms:related_synonym: potassium-dependent sodium/calcium exchanger
 xref: RHEA:69967;   Reactome:R-HSA-5625841 "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+";   Reactome:R-HSA-5626270 "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+";   Reactome:R-HSA-5626356 "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+";   reactome:R-HSA-2514891 "SLC24A1 exchanges 4Na+ for Ca2+, K+";   reactome:R-HSA-425678 "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+";   reactome:R-HSA-5626316 "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+"


show annotations for term's descendants           Sort by:
calcium, potassium:sodium antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc24a1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:64,830,143...64,858,902
Ensembl chr 9:64,830,143...64,858,889 		JBrowse link
G Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 enables ISO
IBA		 (PMID:18166528) MGI
RGD
GO_Central		 PMID:11342562 PMID:12377762 PMID:18166528 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:7175087 RGD:730066 NCBI chr 4:86,901,361...87,148,780
Ensembl chr 4:86,901,361...87,148,714 		JBrowse link
G Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 enables ISO
IBA
ISS
IDA		 (PMID:11294880) MGI
RGD
GO_Central		 PMID:11294880 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:68852 NCBI chr 2:145,009,695...145,484,086
Ensembl chr 2:145,009,674...145,484,086 		JBrowse link
G Slc24a4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 enables IDA
ISO
ISA
IBA		 (MGI:6718234|PMID:27093457)
(PMID:12379639)		 ARUK-UCL
MGI
GO_Central		 PMID:12379639 PMID:27093457 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6718234 NCBI chr12:102,094,986...102,239,562
Ensembl chr12:102,094,992...102,233,350 		JBrowse link
G Slc24a5 solute carrier family 24, member 5 enables ISO
IBA		 (PMID:18166528) MGI
GO_Central		 PMID:18166528 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:124,910,076...124,930,316
Ensembl chr 2:124,910,044...124,930,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        monoatomic ion transmembrane transporter activity 733
          active monoatomic ion transmembrane transporter activity 254
            metal cation:monoatomic cation antiporter activity 40
              solute:potassium antiporter activity 18
                calcium, potassium:sodium antiporter activity 5
Path 2
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        inorganic molecular entity transmembrane transporter activity 684
          inorganic cation transmembrane transporter activity 562
            metal ion transmembrane transporter activity 444
              calcium ion transmembrane transporter activity 140
                calcium:monoatomic cation antiporter activity 12
                  calcium:sodium antiporter activity 9
                    calcium, potassium:sodium antiporter activity 5
paths to the root