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ONTOLOGY REPORT - ANNOTATIONS

Term:protein quality control for misfolded or incompletely synthesized proteins
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Accession:GO:0006515 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
Synonyms:exact_synonym: degradation of misfolded or incompletely synthesized proteins;   misfolded or incompletely synthesized protein breakdown;   misfolded or incompletely synthesized protein catabolic process;   misfolded or incompletely synthesized protein catabolism;   misfolded or incompletely synthesized protein degradation;   protein quality control (PQC)
 broad_synonym: protein quality control by the ubiquitin-proteasome system

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protein quality control for misfolded or incompletely synthesized proteins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 involved_in ISO (PMID:29632312), (PMID:30244831), (PMID:31011209), (PMID:32075755) UniProt PMID:29632312 PMID:30244831 PMID:31011209 PMID:32075755 NCBI chrNW_004955453:14,196,728...14,204,344
Ensembl chrNW_004955453:14,196,927...14,203,826 		JBrowse link
G Atxn3 ataxin 3 involved_in ISO (PMID:21855799) UniProt PMID:21855799 NCBI chrNW_004955438:14,405,415...14,443,457
Ensembl chrNW_004955438:14,405,643...14,440,009 		JBrowse link
G Fbxl17 F-box and leucine rich repeat protein 17 involved_in ISO (PMID:30190310) UniProt PMID:30190310 NCBI chrNW_004955418:6,314,503...6,758,531 JBrowse link
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:14675537) BHF-UCL PMID:14675537 NCBI chrNW_004955543:348,314...378,391
Ensembl chrNW_004955543:348,019...378,071 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISO (PMID:20038677) UniProt PMID:20038677 NCBI chrNW_004955464:1,305,802...1,393,190
Ensembl chrNW_004955464:1,305,802...1,393,788 		JBrowse link
G Saysd1 SAYSVFN motif domain containing 1 involved_in ISO (PMID:36848233) UniProt PMID:36848233 NCBI chrNW_004955437:4,369,140...4,375,405
Ensembl chrNW_004955437:4,369,141...4,375,968 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:16831871)
(PMID:21855799)		 BHF-UCL
UniProt		 PMID:16831871 PMID:21855799 NCBI chrNW_004955442:16,521,130...16,523,733
Ensembl chrNW_004955442:16,521,130...16,523,468 		JBrowse link
G Ube2w ubiquitin conjugating enzyme E2 W involved_in ISO (PMID:21855799) UniProt PMID:21855799 NCBI chrNW_004955444:6,454,043...6,536,719
Ensembl chrNW_004955444:6,454,049...6,509,505 		JBrowse link
G Yme1l1 YME1 like 1 ATPase involved_in ISO (PMID:22262461) UniProt PMID:22262461 NCBI chrNW_004955429:2,550,611...2,572,472
Ensembl chrNW_004955429:2,549,954...2,572,889 		JBrowse link
G Zer1 zyg-11 related cell cycle regulator involved_in ISO (PMID:31273098) UniProt PMID:31273098 NCBI chrNW_004955570:1,138,477...1,153,246
Ensembl chrNW_004955570:1,138,477...1,152,198 		JBrowse link
G Zswim8 zinc finger SWIM-type containing 8 involved_in ISO (PMID:35989311) UniProt PMID:35989311 NCBI chrNW_004955437:18,099,416...18,113,936
Ensembl chrNW_004955437:18,099,589...18,114,726 		JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator involved_in ISO (PMID:31273098) UniProt PMID:31273098 NCBI chrNW_004955464:6,354,510...6,404,668
Ensembl chrNW_004955464:6,354,510...6,405,041 		JBrowse link
cytoplasm protein quality control term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubr4 ubiquitin protein ligase E3 component n-recognin 4 involved_in ISO (PMID:29033132) UniProt PMID:29033132 NCBI chrNW_004955527:57,335...185,727
Ensembl chrNW_004955527:57,335...185,727 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in ISO (PMID:29033132) UniProt PMID:29033132 NCBI chrNW_004955417:26,997,572...27,085,511
Ensembl chrNW_004955417:26,998,513...27,083,005 		JBrowse link
G Vcp valosin containing protein involved_in ISO (PMID:29033132) UniProt PMID:29033132 NCBI chrNW_004955472:1,111,649...1,124,076
Ensembl chrNW_004955472:1,107,164...1,124,076 		JBrowse link
cytoplasm protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf126 ring finger protein 126 involved_in ISO (PMID:24981174) UniProt PMID:24981174 NCBI chrNW_004955495:7,083,952...7,098,442
Ensembl chrNW_004955495:7,095,336...7,102,757 		JBrowse link
G Ubr4 ubiquitin protein ligase E3 component n-recognin 4 involved_in ISO (PMID:29033132) UniProt PMID:29033132 NCBI chrNW_004955527:57,335...185,727
Ensembl chrNW_004955527:57,335...185,727 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in ISO (PMID:29033132) UniProt PMID:29033132 NCBI chrNW_004955417:26,997,572...27,085,511
Ensembl chrNW_004955417:26,998,513...27,083,005 		JBrowse link
mitochondrial protein quality control term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 involved_in ISO (PMID:26504172), (PMID:30683687), (PMID:34718584) UniProt PMID:26504172 PMID:30683687 PMID:34718584 NCBI chrNW_004955402:1,037,414...1,069,165
Ensembl chrNW_004955402:1,037,402...1,069,165 		JBrowse link
G Oxa1l OXA1L mitochondrial inner membrane protein involved_in ISO (PMID:38199007) UniProt PMID:38199007 NCBI chrNW_004955409:37,513,925...37,519,250
Ensembl chrNW_004955409:37,514,177...37,519,376 		JBrowse link
G Tmem126a transmembrane protein 126A involved_in ISO (PMID:38199007) UniProt PMID:38199007 NCBI chrNW_004955414:7,214,408...7,224,499
Ensembl chrNW_004955414:7,216,286...7,224,475 		JBrowse link
nuclear protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akirin2 akirin 2 acts_upstream_of_positive_effect ISO (PMID:34711951) UniProt PMID:34711951 NCBI chrNW_004955411:14,600,106...14,619,374
Ensembl chrNW_004955411:14,600,106...14,619,069 		JBrowse link
G Cul3 cullin 3 involved_in ISO (PMID:27561354) UniProt PMID:27561354 NCBI chrNW_004955453:9,546,554...9,629,976
Ensembl chrNW_004955453:9,564,522...9,629,976 		JBrowse link
G Klhl15 kelch like family member 15 involved_in ISO (PMID:27561354) UniProt PMID:27561354 NCBI chrNW_004955509:4,377,975...4,439,287
Ensembl chrNW_004955509:4,375,240...4,439,287 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in ISO (PMID:37478846), (PMID:37478862) UniProt PMID:37478846 PMID:37478862 NCBI chrNW_004955417:26,997,572...27,085,511
Ensembl chrNW_004955417:26,998,513...27,083,005 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12571
    cellular process 12010
      metabolic process 7972
        macromolecule metabolic process 6547
          protein metabolic process 3553
            proteolysis 1042
              proteolysis involved in protein catabolic process 580
                protein quality control for misfolded or incompletely synthesized proteins 22
                  cytoplasm protein quality control + 4
                  mitochondrial protein quality control 3
                  nuclear protein quality control by the ubiquitin-proteasome system + 4
paths to the root