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ONTOLOGY REPORT - ANNOTATIONS

Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.
Synonyms:only_in_taxon: NCBITaxon:6072 ! Eumetazoa


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insulin receptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IGF1R insulin like growth factor 1 receptor part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387 		JBrowse link
G INSR insulin receptor part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046 		JBrowse link
G INSRR insulin receptor related receptor part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 7:41,161,036...41,176,739
Ensembl chr 7:41,161,333...41,175,940 		JBrowse link
G IRS1 insulin receptor substrate 1 part_of ISO PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr25:39,624,554...39,687,991 JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 ISO RGD PMID:14525909 RGD:11038810 NCBI chr28:8,834,530...9,063,739
Ensembl chr28:8,837,338...9,063,777 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18905
    protein-containing complex 6506
      receptor complex 415
        plasma membrane signaling receptor complex 198
          insulin receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 18905
    cellular anatomical entity 18654
      cell periphery 5883
        plasma membrane 5399
          plasma membrane protein complex 603
            plasma membrane signaling receptor complex 198
              insulin receptor complex 5
paths to the root