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ONTOLOGY REPORT - ANNOTATIONS

Term:alpha2-adrenergic receptor activity
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Accession:GO:0004938 term browser browse the term
Definition:Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.
Synonyms:exact_synonym: alpha2 adrenoceptor
 xref: Reactome:R-HSA-400071 "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline"


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alpha2-adrenergic receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A enables ISO (PMID:17992256)
(PMID:1354394)
(PMID:10948191)		 RGD
MGI
BHF-UCL		 PMID:1354394 PMID:1645350 PMID:10948191 PMID:17992256 RGD:1304193 NCBI chr10:107,669,860...107,673,685 JBrowse link
G ADRA2B adrenoceptor alpha 2B enables ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro
UniProt		 PMID:2158103 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:631714 NCBI chr2A:103,198,432...103,202,506
Ensembl chr2A:97,040,126...97,041,472 		JBrowse link
G ADRA2C adrenoceptor alpha 2C enables ISO (PMID:17215105)
(PMID:10948191)		 BHF-UCL
Reactome		 PMID:10948191 PMID:17215105 NCBI chr 4:3,904,346...3,906,577 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 17686
    molecular transducer activity 1275
      signaling receptor activity 1275
        transmembrane signaling receptor activity 1091
          G protein-coupled receptor activity 715
            G protein-coupled amine receptor activity 39
              adrenergic receptor activity 10
                alpha-adrenergic receptor activity 6
                  alpha2-adrenergic receptor activity 3
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