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ONTOLOGY REPORT - ANNOTATIONS

Term:uracil DNA N-glycosylase activity
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Accession:GO:0004844 term browser browse the term
Definition:Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
Synonyms:exact_synonym: uracil-DNA glycosylase activity
 xref: EC:3.2.2.27;   Reactome:R-HSA-9817512 "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3";   reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase";   reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase"


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uracil DNA N-glycosylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smug1 single-strand selective monofunctional uracil DNA glycosylase enables ISO
IBA
ISS
ISA		 (PMID:12718543) RGD
GO_Central
HGNC-UCL
MGI		 PMID:12718542 PMID:12718543 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:2317001 NCBI chr15:103,061,717...103,077,360
Ensembl chr15:103,061,717...103,075,519 		JBrowse link
G Tdg thymine DNA glycosylase enables ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr10:82,465,649...82,486,633
Ensembl chr10:82,465,662...82,486,633 		JBrowse link
G Tdg-ps thymine DNA glycosylase, pseudogene enables ISO GO_Central GO_REF:0000119 NCBI chr15:82,400,497...82,403,443
Ensembl chr15:82,400,512...82,403,479 		JBrowse link
G Ung uracil DNA glycosylase enables ISO
IBA
IDA
IMP
TAS		 (PMID:10871356)
(PMID:15494304)		 RGD
GO_Central
MGI
Reactome		 PMID:10871356 PMID:11292851 PMID:12167490 PMID:15494304 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1599704 RGD:634481 Reactome:R-MMU-9817522 NCBI chr 5:114,268,427...114,277,382
Ensembl chr 5:114,268,447...114,277,384 		JBrowse link
G/U mismatch-specific uracil-DNA glycosylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdg thymine DNA glycosylase enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr10:82,465,649...82,486,633
Ensembl chr10:82,465,662...82,486,633 		JBrowse link
G Tdg-ps thymine DNA glycosylase, pseudogene enables ISO GO_Central GO_REF:0000119 NCBI chr15:82,400,497...82,403,443
Ensembl chr15:82,400,512...82,403,479 		JBrowse link
single-strand selective uracil DNA N-glycosylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smug1 single-strand selective monofunctional uracil DNA glycosylase enables ISO
ISS		 (PMID:12718543) GO_Central
HGNC-UCL		 PMID:12718543 GO_REF:0000096 GO_REF:0000119 NCBI chr15:103,061,717...103,077,360
Ensembl chr15:103,061,717...103,075,519 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28796
    catalytic activity 5725
      catalytic activity, acting on a nucleic acid 647
        catalytic activity, acting on DNA 326
          DNA N-glycosylase activity 14
            deaminated base DNA N-glycosylase activity 4
              uracil DNA N-glycosylase activity 4
                G/U mismatch-specific uracil-DNA glycosylase activity 2
                single-strand selective uracil DNA N-glycosylase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 28796
    catalytic activity 5725
      hydrolase activity 2474
        hydrolase activity, acting on glycosyl bonds 145
          hydrolase activity, hydrolyzing N-glycosyl compounds 44
            DNA N-glycosylase activity 14
              deaminated base DNA N-glycosylase activity 4
                uracil DNA N-glycosylase activity 4
                  G/U mismatch-specific uracil-DNA glycosylase activity 2
                  single-strand selective uracil DNA N-glycosylase activity 1
paths to the root