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ONTOLOGY REPORT - ANNOTATIONS

Term:tubulin-tyrosine ligase activity
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Accession:GO:0004835 term browser browse the term
Definition:Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
Synonyms:exact_synonym: tubulinyl-tyrosine ligase activity
 related_synonym: TTL activity;   alpha-tubulin:L-tyrosine ligase (ADP-forming)
 xref: EC:6.3.2.25;   MetaCyc:6.3.2.25-RXN;   RHEA:17605;   Reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin"


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tubulin-tyrosine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttl tubulin tyrosine ligase enables IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:25908662)
GO_REF:0000033
MGI:3584264 (PMID:15899979)		 Ensembl
RGD
GO_Central		 PMID:15899979 PMID:25908662 PMID:9108330 GO_REF:0000033 GO_REF:0000107, RGD:634442 NCBI chr 3:116,298,813...116,328,538
Ensembl chr 3:116,298,797...116,328,538 		JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 NOT|enables ISO (PMID:23251473) RGD PMID:23251473 NCBI chr 7:114,731,890...114,751,237
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      catalytic activity, acting on a protein 2444
        tubulin-tyrosine ligase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      ligase activity 177
        ligase activity, forming carbon-nitrogen bonds 51
          acid-amino acid ligase activity 24
            tubulin-tyrosine ligase activity 2
paths to the root