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ONTOLOGY REPORT - ANNOTATIONS

Term:acid-amino acid ligase activity
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Accession:GO:0016881 term browser browse the term
Definition:Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Synonyms:exact_synonym: peptide synthase activity
 xref: EC:6.3.2


show annotations for term's descendants           Sort by:
acid-amino acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase enables IEA GO_REF:0000002
GO_REF:0000117 		InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Ghdc GH3 domain containing enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:85,693,612...85,697,833
Ensembl chr10:85,693,616...85,697,865 		JBrowse link
G Ttl tubulin tyrosine ligase enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 3:116,298,813...116,328,538
Ensembl chr 3:116,298,797...116,328,538 		JBrowse link
G Ttll10 tubulin tyrosine ligase like 10 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 5:166,630,147...166,644,114
Ensembl chr 5:166,630,152...166,653,707 		JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 7:114,731,890...114,751,237
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
G Ttll3 tubulin tyrosine ligase like 3 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889 		JBrowse link
G Ttll8 tubulin tyrosine ligase like 8 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 7:120,000,638...120,046,556
Ensembl chr 7:120,001,794...120,045,075 		JBrowse link
carnosine synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carns1 carnosine synthase 1 enables ISO
IEA
IBA 		(PMID:20097752), (PMID:24891507)
GO_REF:0000002
GO_REF:0000033 		RGD
InterPro
GO_Central		 PMID:20097752 PMID:24891507 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:201,459,061...201,470,019
Ensembl chr 1:201,459,076...201,469,845 		JBrowse link
glutamate-cysteine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit enables IMP
IEA
ISO
IBA
ISS
IDA 		GO_REF:0000116
GO_REF:0000003
GO_REF:0000107
GO_REF:0000002
MGI:2429419 (PMID:10966520), (PMID:11118286), (PMID:12384496), (PMID:15288121), (PMID:16081425)
GO_REF:0000033
GO_REF:0000104
(PMID:11972604), (PMID:12663448), (PMID:16183645), (PMID:8104187), (PMID:9675072), (PMID:9841880)
GO_REF:0000024 		RHEA
UniProt
Ensembl
InterPro
RGD
GO_Central		 PMID:8104187 PMID:9675072 PMID:9841880 PMID:10966520 PMID:11118286 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116, RGD:1582661, RGD:11049538 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit contributes_to IDA
IEA
ISO
IMP 		GO_REF:0000107
(PMID:16183645) 		Ensembl
RGD		 PMID:16183645 PMID:8104188 PMID:16183645 GO_REF:0000107, RGD:632762, RGD:1582661 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
glutathione synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gss glutathione synthetase enables IDA
IEA
IBA
ISO 		GO_REF:0000104
GO_REF:0000033
(PMID:8660701)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000116
GO_REF:0000003 		UniProt
GO_Central
RGD
Ensembl
InterPro
RHEA		 PMID:8660701 PMID:7862666 PMID:10964706 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116, RGD:69853, RGD:1599340 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
homocarnosine synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carns1 carnosine synthase 1 enables ISO
IBA 		(PMID:20097752)
GO_REF:0000033 		RGD
GO_Central		 PMID:20097752 GO_REF:0000033 NCBI chr 1:201,459,061...201,470,019
Ensembl chr 1:201,459,076...201,469,845 		JBrowse link
phosphopantothenate--cysteine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppcs phosphopantothenoylcysteine synthetase enables ISO
IEA
IBA 		(PMID:11923312), (PMID:29754768)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:11923312 PMID:29754768 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933 		JBrowse link
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000066810 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 1:52,389,359...52,390,972 JBrowse link
G LOC100359876 multifunctional protein ADE2-like enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002
GO_REF:0000003 		GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr  X:4,032,827...4,034,310
Ensembl chr  X:4,032,895...4,033,896 		JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase enables ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:27590927), (PMID:31600779)
GO_REF:0000002
GO_REF:0000003
GO_REF:0000033
GO_REF:0000116 		UniProt
RGD
InterPro
GO_Central
RHEA		 PMID:27590927 PMID:31600779 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635 		JBrowse link
protein-glutamic acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll4 tubulin tyrosine ligase like 4 enables ISO
IEA 		(PMID:17499049), (PMID:26829768)
GO_REF:0000107 		RGD
Ensembl		 PMID:17499049 PMID:26829768 GO_REF:0000107 NCBI chr 9:76,221,659...76,258,219
Ensembl chr 9:76,221,796...76,251,301 		JBrowse link
G Ttll6 tubulin tyrosine ligase like 6 enables ISO (PMID:26829768), (PMID:32747782) RGD PMID:26829768 PMID:32747782 NCBI chr10:81,081,985...81,118,009
Ensembl chr10:81,091,975...81,127,234 		JBrowse link
protein-glutamic acid ligase activity, elongating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 7:116,499,536...116,528,833
Ensembl chr 7:114,619,508...114,648,761 		JBrowse link
G Ttll9 tubulin tyrosine ligase like 9 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 3:141,429,351...141,475,965
Ensembl chr 3:141,429,444...141,475,865 		JBrowse link
protein-glycine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll10 tubulin tyrosine ligase like 10 NOT|enables ISO
ISS 		(PMID:19524510)
GO_REF:0000024 		RGD
UniProt		 PMID:19524510 GO_REF:0000024 NCBI chr 5:166,630,147...166,644,114
Ensembl chr 5:166,630,152...166,653,707 		JBrowse link
G Ttll3 tubulin tyrosine ligase like 3 enables ISO (PMID:19524510) RGD PMID:19524510 NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889 		JBrowse link
G Ttll8 tubulin tyrosine ligase like 8 enables ISO
IEA 		(PMID:19524510)
GO_REF:0000107 		RGD
Ensembl		 PMID:19524510 GO_REF:0000107 NCBI chr 7:120,000,638...120,046,556
Ensembl chr 7:120,001,794...120,045,075 		JBrowse link
protein-glycine ligase activity, elongating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll10 tubulin tyrosine ligase like 10 enables ISS
ISO
IBA 		GO_REF:0000024
(PMID:19524510)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:19524510 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:166,630,147...166,644,114
Ensembl chr 5:166,630,152...166,653,707 		JBrowse link
protein-glycine ligase activity, initiating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll3 tubulin tyrosine ligase like 3 enables ISO
IBA 		(PMID:19524510), (PMID:33414192)
GO_REF:0000033 		RGD
GO_Central		 PMID:19524510 PMID:33414192 GO_REF:0000033 NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889 		JBrowse link
G Ttll8 tubulin tyrosine ligase like 8 enables ISO
IEA
IBA 		(PMID:19524510), (PMID:28576883), (PMID:33414192)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:19524510 PMID:28576883 PMID:33414192 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:120,000,638...120,046,556
Ensembl chr 7:120,001,794...120,045,075 		JBrowse link
tetrahydrofolylpolyglutamate synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase enables IDA
IEA
ISO
IBA 		GO_REF:0000002
GO_REF:0000003
(PMID:11772020), (PMID:24532667), (PMID:7592937), (PMID:9054377)
GO_REF:0000033
(PMID:10964921), (PMID:3619447), (PMID:8408020)
(PMID:25164808) 		InterPro
UniProt
RGD
GO_Central		 PMID:3619447 PMID:7592937 PMID:8408020 PMID:9054377 PMID:10964921 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033, RGD:2315105 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
tubulin-glutamic acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpgs1 tubulin polyglutamylase complex subunit 1 enables ISO
IEA
IBA 		(PMID:17360631)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:17360631 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:10,029,842...10,035,764
Ensembl chr 7:10,029,854...10,035,764 		JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 enables ISO
IEA
IBA 		(PMID:34782749)
GO_REF:0000107
(PMID:15890843), (PMID:30420556)
GO_REF:0000033
GO_REF:0000117 		RGD
Ensembl
GO_Central
UniProt		 PMID:15890843 PMID:30420556 PMID:34782749 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 7:116,499,536...116,528,833
Ensembl chr 7:114,619,508...114,648,761 		JBrowse link
G Ttll11 tubulin tyrosine ligase like 11 enables ISO
IEA
IBA 		(PMID:17499049), (PMID:20530212)
GO_REF:0000117
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:17499049 PMID:20530212 GO_REF:0000033 GO_REF:0000117 NCBI chr 3:19,109,891...19,335,077
Ensembl chr 3:19,110,284...19,335,969 		JBrowse link
G Ttll13 tubulin tyrosine ligase like 13 enables IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000117
(PMID:17499049) 		GO_Central
Ensembl
UniProt
RGD		 PMID:17499049 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:134,197,801...134,213,083
Ensembl chr 1:134,197,801...134,218,718 		JBrowse link
G Ttll2 tubulin tyrosine ligase like 2 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000117 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:52,967,183...52,976,690
Ensembl chr 1:52,968,408...52,976,697 		JBrowse link
G Ttll4 tubulin tyrosine ligase like 4 enables IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000117
(PMID:17499049), (PMID:21074048) 		GO_Central
Ensembl
UniProt
RGD		 PMID:17499049 PMID:21074048 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:76,221,659...76,258,219
Ensembl chr 9:76,221,796...76,251,301 		JBrowse link
G Ttll5 tubulin tyrosine ligase like 5 enables IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000117
(PMID:17499049) 		GO_Central
Ensembl
UniProt
RGD		 PMID:17499049 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:105,483,091...105,700,920
Ensembl chr 6:105,483,191...105,700,934 		JBrowse link
G Ttll6 tubulin tyrosine ligase like 6 enables IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000117
(PMID:17499049), (PMID:20530212), (PMID:21074048), (PMID:32747782) 		GO_Central
UniProt
RGD		 PMID:17499049 PMID:20530212 PMID:21074048 PMID:32747782 GO_REF:0000033 GO_REF:0000117 NCBI chr10:81,081,985...81,118,009
Ensembl chr10:81,091,975...81,127,234 		JBrowse link
G Ttll7 tubulin tyrosine ligase like 7 enables ISO
IEA
IBA 		(PMID:25959773)
GO_REF:0000107
GO_REF:0000117
(PMID:16901895), (PMID:17499049), (PMID:19152315)
GO_REF:0000033 		RGD
Ensembl
UniProt
GO_Central		 PMID:16901895 PMID:17499049 PMID:19152315 PMID:25959773 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 2:235,765,786...235,889,047
Ensembl chr 2:235,765,835...235,885,047 		JBrowse link
G Ttll9 tubulin tyrosine ligase like 9 enables ISS
ISO
IBA
IEA 		GO_REF:0000024
(PMID:27257088)
GO_REF:0000033
GO_REF:0000117 		UniProt
RGD
GO_Central		 PMID:27257088 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 NCBI chr 3:141,429,351...141,475,965
Ensembl chr 3:141,429,444...141,475,865 		JBrowse link
tubulin-tyrosine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttl tubulin tyrosine ligase enables IDA
IEA
ISO
IBA 		GO_REF:0000116
GO_REF:0000003
GO_REF:0000107
(PMID:25908662)
GO_REF:0000033
MGI:3584264 (PMID:15899979) 		RHEA
UniProt
Ensembl
RGD
GO_Central		 PMID:15899979 PMID:25908662 PMID:9108330 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:634442 NCBI chr 3:116,298,813...116,328,538
Ensembl chr 3:116,298,797...116,328,538 		JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 NOT|enables ISO (PMID:23251473) RGD PMID:23251473 NCBI chr 7:114,731,890...114,751,237
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21054
    catalytic activity 6213
      ligase activity 180
        ligase activity, forming carbon-nitrogen bonds 53
          acid-amino acid ligase activity 25
            2,3-dihydroxybenzoate-serine ligase activity 0
            D-alanine-D-alanine ligase activity 0
            D-alanine-D-serine ligase activity 0
            D-alanine-alanyl-poly(glycerolphosphate) ligase activity 0
            L-amino-acid alpha-ligase activity 0
            L-propargylglycine--L-glutamate ligase activity 0
            N-(4-aminobenzoyl)-L-glutamate synthetase activity 0
            N-(4-hydroxybenzoyl)-L-glutamate synthetase activity 0
            N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity 0
            N-benzoyl-L-glutamate synthetase activity 0
            N-vanillate-L-glutamate synthetase activity 0
            UDP-N-acetylmuramate-L-alanine ligase activity 0
            UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity 0
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity 0
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity 0
            UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity 0
            UDP-N-acetylmuramoylalanine-D-glutamate ligase activity 0
            UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity 0
            UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity 0
            aerobactin synthase activity 0
            amino acid ligation activity by nonribosomal peptide synthase 0
            carnitine-CoA ligase activity 0
            carnosine synthase activity 1
            coenzyme F420-0 gamma-glutamyl ligase activity + 0
            coenzyme F420-2 alpha-glutamyl ligase activity 0
            cyanophycin synthetase activity + 0
            cyclopeptine synthase activity 0
            dihydrofolate synthase activity 0
            gamma-glutamylhistamine synthase activity 0
            glutamate-cysteine ligase activity 2
            glutathione synthase activity 1
            homocarnosine synthase activity 1
            homoglutathione synthase activity 0
            indole-3-acetic acid amido synthetase activity + 0
            jasmonoyl-L-amino acid ligase activity 0
            pantoate-beta-alanine ligase activity 0
            phosphopantothenate--cysteine ligase activity 1
            phosphoribosylaminoimidazolesuccinocarboxamide synthase activity 3
            protein-glutamic acid ligase activity + 10
            protein-glycine ligase activity + 3
            tetrahydrofolylpolyglutamate synthase activity 1
            tubulin-tyrosine ligase activity 2
            tyrosine-arginine ligase activity 0
paths to the root