CAAX-protein geranylgeranyltransferase activity - Ontology Report

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Term:	CAAX-protein geranylgeranyltransferase activity	go back to main search page
Accession:	GO:0004662	browse the term
Definition:	Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
Synonyms:	exact_synonym:	GGTase-I activity; GGTaseI activity; geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity; geranylgeranyltransferase type I activity
	related_synonym:	protein geranylgeranyltransferase type I; type I protein geranyl-geranyltransferase activity
	xref:	EC:2.5.1.59; MetaCyc:RXN-3701

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FNTA

farnesyltransferase, CAAX box, subunit alpha

contributes_to
enables

GO_REF:0000118 RGD:2302973

NCBI chr17:11,928,327...11,953,139
Ensembl chr17:11,928,358...11,951,684

protein geranylgeranyltransferase type I subunit beta

enables
contributes_to

GO_REF:0000003 GO_REF:0000033 GO_REF:0000118

NCBI chr 2:119,386,692...119,440,834
Ensembl chr 2:119,383,387...119,440,322

Term paths to the root

Path 1
Term	Annotations
molecular_function	18691
catalytic activity	5667
catalytic activity, acting on a protein	2329
protein prenyltransferase activity	7
protein geranylgeranyltransferase activity	5
CAAX-protein geranylgeranyltransferase activity	2
Path 2
Term	Annotations
molecular_function	18691
catalytic activity	5667
transferase activity	2373
transferase activity, transferring alkyl or aryl (other than methyl) groups	67
prenyltransferase activity	17
protein prenyltransferase activity	7
protein geranylgeranyltransferase activity	5
CAAX-protein geranylgeranyltransferase activity	2

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