ONTOLOGY REPORT - ANNOTATIONS |
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Term: | nitric-oxide synthase activity |
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Accession: | GO:0004517
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browse the term
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Definition: | Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. |
Synonyms: | related_synonym: | L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity; NADPH-diaphorase activity; NO synthase activity; endothelium-derived relaxation factor-forming enzyme activity; endothelium-derived relaxing factor synthase activity; nitric oxide synthetase activity |
| xref: | EC:1.14.13.39; MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN; RHEA:19897; reactome:R-HSA-202127 "eNOS synthesizes NO"; reactome:R-HSA-418436 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)" |
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Nos1 |
nitric oxide synthase 1 |
enables |
TAS IDA IEA ISO IBA |
GO_REF:0000116 GO_REF:0000003 PMID:1383204 PMID:17029414 PMID:18591664 PMID:23549614 GO_REF:0000117 (PMID:1689048), (PMID:35772285) PMID:1712077 GO_REF:0000033 (PMID:11591728), (PMID:7545544) |
RHEA UniProt RGD GO_Central |
PMID:1689048 PMID:7545544 PMID:11591728 PMID:35772285 PMID:12526033 PMID:17029414 PMID:16387842 PMID:14966111 PMID:1383204 PMID:17029414 PMID:18591664 PMID:23549614 PMID:35772285 PMID:1712077 More...
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GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:727494, RGD:1598372, RGD:1580263, RGD:1358520, RGD:8553334, RGD:1598372, RGD:8554165, RGD:14995314, RGD:329955539, RGD:401827139 |
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nos2 |
nitric oxide synthase 2 |
enables |
TAS IDA IEA ISO IBA |
GO_REF:0000003 GO_REF:0000116 PMID:9851365 GO_REF:0000117 (PMID:35772285), (PMID:7504305), (PMID:7682706) GO_REF:0000033 (PMID:1383204), (PMID:9271491) |
UniProt RHEA RGD GO_Central |
PMID:1383204 PMID:7504305 PMID:7682706 PMID:9271491 PMID:35772285 PMID:12048156 PMID:11788371 PMID:16172396 PMID:9851365 More...
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GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:625548, RGD:70247, RGD:1580262, RGD:8656011 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3 |
nitric oxide synthase 3 |
enables |
IMP IDA IEA ISO IBA |
GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 (PMID:1378832), (PMID:19666465), (PMID:23707606), (PMID:35772285), (PMID:7488039) GO_REF:0000033 MGI:1857229 (PMID:15647265) |
UniProt RHEA RGD GO_Central |
PMID:1378832 PMID:7488039 PMID:15647265 PMID:19666465 PMID:23707606 PMID:35772285 PMID:12388111 PMID:12388111 More...
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GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:628542, RGD:628542 |
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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