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ONTOLOGY REPORT - ANNOTATIONS

Term:second spliceosomal transesterification activity
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Accession:GO:0000386 term browser browse the term
Definition:Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
Synonyms:broad_synonym: 3'-splice site cleavage, exon ligation
 related_synonym: lariat formation, 5'-splice site cleavage
 xref: Reactome:R-HSA-9770236 "Formation of the Spliceosomal P complex and exon ligation"


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second spliceosomal transesterification activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slu7 SLU7 homolog, splicing factor enables ISS
ISO		 PMID:15181151
(PMID:10197984)		 RGD PMID:10197984 PMID:15181151 RGD:1304333 NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349 		JBrowse link
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  molecular_function 20483
    catalytic activity 6036
      catalytic activity, acting on a nucleic acid 630
        catalytic activity, acting on RNA 396
          second spliceosomal transesterification activity 1
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