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Ontology Browser
Term:
second spliceosomal transesterification activity (GO:0000386)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1) Naked Mole-rat: (1) Green Monkey: (1)
Parent Terms Term With Siblings Child Terms
catalytic activity, acting on a rRNA +   
catalytic activity, acting on a tRNA +   
DNA/RNA helicase activity +   
first spliceosomal transesterification activity 
mRNA 5'-diphosphatase activity  
mRNA 5'-triphosphate monophosphatase activity  
oxidative RNA demethylase activity +   
RNA glycosylase activity +  
RNA guanylyltransferase activity +   
RNA helicase activity +   
RNA ligase activity +   
RNA methyltransferase activity +   
RNA NAD+-cap (NAD+-forming) hydrolase activity  
RNA NAD-cap (NMN-forming) hydrolase activity  
RNA nuclease activity +   
RNA polymerase activity +   
RNA topoisomerase activity  
RNA uridylyltransferase activity  
RNA-3'-phosphate cyclase activity  
rRNA pseudouridine synthase activity +  
second spliceosomal transesterification activity  
Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
snRNA pseudouridine synthase activity 
template-free RNA nucleotidyltransferase  
tyrosyl-RNA phosphodiesterase activity  

Synonyms
Broad Synonyms: 3'-splice site cleavage, exon ligation
Related Synonyms: lariat formation, 5'-splice site cleavage
Xrefs: Reactome:R-HSA-9770236 "Formation of the Spliceosomal P complex and exon ligation"
Definition Sources: GOC:krc, ISBN:0879695897, PMID:19239890

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