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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Crush Syndrome
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Accession:DOID:9000921 term browser browse the term
Definition:Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.
Synonyms:exact_synonym: Crush Syndromes
 primary_id: MESH:D003444;   RDO:0005298
 xref: EFO:1001299

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Crush Syndrome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mb myoglobin IDA RGD PMID:12558149 RGD:1582428 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21122
    syndrome 10725
      Crush Syndrome 1
Path 2
Term Annotations click to browse term
  disease 21122
    Pathological Conditions, Signs and Symptoms 13262
      Pathologic Processes 7934
        Shock 415
          Traumatic Shock 3
            Crush Syndrome 1
paths to the root