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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Myeloid Leukemia, Chronic-Phase
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Accession:DOID:9002867 term browser browse the term
Definition:The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.
Synonyms:exact_synonym: Chronic Granulocytic Leukemia, Stable Phase;   Chronic Myelogenous Leukemia, Chronic Phase;   Chronic Myeloid Leukemia, Chronic Phase;   Chronic Myeloid Leukemia, Stable-Phase;   Granulocytic Leukemia, Chronic Phase;   Myelogenous Leukemia, Chronic Phase;   Myeloid Leukemia, Stable Phase
 primary_id: MESH:D015466


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Myeloid Leukemia, Chronic-Phase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase disease_progression ISO DNA:hypermethylation:promoter RGD PMID:11559572 PMID:19344397 RGD:11038809 RGD:11038811 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708 		JBrowse link
G BCR BCR activator of RhoGEF and GTPase disease_progression ISO RGD PMID:19344397 RGD:11038809 NCBI chr14:49,208,662...49,322,109
Ensembl chr14:49,208,762...49,322,103 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 treatment ISO DNA:polymorphism:intron :6986A>G (human) RGD PMID:23394475 RGD:11353797 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit treatment ISO DNA:SNP: :rs11615 (human) RGD PMID:22821389 RGD:11252165 NCBI chr 6:51,783,537...51,808,898
Ensembl chr 6:51,783,478...51,798,984 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor disease_progression ISO mRNA,protein:increased expression:mononuclea cell, CD34+ cell RGD PMID:19887785 PMID:23411466 RGD:11040457 RGD:11040461 NCBI chr 4:124,619,887...124,629,638
Ensembl chr 4:124,621,261...124,629,638 		JBrowse link
G GFI1B growth factor independent 1B transcriptional repressor ISO mRNA:increased expression:blood: RGD PMID:19360458 RGD:11040460 NCBI chr 1:272,701,386...272,715,551
Ensembl chr 1:272,702,184...272,715,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15390
    disease of cellular proliferation 7396
      Neoplasms by Histologic Type 5125
        leukemia 629
          myeloid leukemia 427
            chronic myeloid leukemia 84
              Myeloid Leukemia, Chronic-Phase 6
Path 2
Term Annotations click to browse term
  disease 15390
    disease of anatomical entity 15084
      Hemic and Lymphatic Diseases 4087
        hematopoietic system disease 3612
          Hematologic Neoplasms 1020
            Bone Marrow Neoplasms 469
              bone marrow cancer 469
                myeloid neoplasm 285
                  chronic myeloid leukemia 84
                    Myeloid Leukemia, Chronic-Phase 6
paths to the root