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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Wernicke-Korsakoff syndrome
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Accession:DOID:10915 term browser browse the term
Definition:A nutritional deficiency disease that is characterized by ophthalmoplegia, ataxia, change in mental status and acute onset of severe memory impairment without any dysfunction in intellectual abilities, and has_material_basis_in thiamine deficiency. (DO)
Synonyms:exact_synonym: ALCOHOL-INDUCED ENCEPHALOPATHY;   Korsakoff Psychosis;   Korsakoff psychoses;   Korsakoff syndrome;   Korsakoff's psychosis;   Korsakoff's syndrome;   Korsakov psychosis;   Korsakov's psychosis;   Wernicke-Korsakoff syndromes;   transketolase defect
 primary_id: MESH:D020915
 alt_id: MIM:277730
 xref: EFO:1001242;   NCI:C35764;   NCI:C84803
For additional species annotation, visit the Alliance of Genome Resources.

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Wernicke-Korsakoff syndrome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin ISO associated with alcohol dependence;protein:increased expression:plasma
protein:decreased expression:cerebrospinal fluid 		RGD PMID:2425205 PMID:7662042 RGD:596933082 RGD:596933106 NCBI chrNW_004624741:4,208,305...4,210,097
Ensembl chrNW_004624741:4,208,329...4,210,071 		JBrowse link
G Pomc proopiomelanocortin ISO protein:increased expression:mammillary body RGD PMID:1650797 RGD:407572523 NCBI chrNW_004624738:7,442,223...7,448,513
Ensembl chrNW_004624738:7,442,292...7,445,020 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14234
    Chemically-Induced Disorders 1179
      substance-related disorder 653
        Alcohol-Related Disorders 381
          Alcohol Amnestic Disorder 2
            Wernicke-Korsakoff syndrome 2
Path 2
Term Annotations click to browse term
  disease 14234
    Nutritional and Metabolic Diseases 6956
      disease of metabolism 6956
        acquired metabolic disease 2120
          nutrition disease 765
            Malnutrition 240
              nutritional deficiency disease 221
                Avitaminosis 182
                  Vitamin B Deficiency 137
                    thiamine deficiency disease 6
                      Wernicke-Korsakoff syndrome 2
paths to the root