Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:severe COVID-19
go back to main search page
Accession:DOID:0081013 term browser browse the term
Definition:A COVID-19 that is characterized by any of (1) Oxygen saturation < 90% on room air, (2) Respiratory rate > 30 breaths/min in adults and children > 5 years old, ≥ 60 breaths/min in children < 2 months old, ≥ 50 in children 2–11 months old, and ≥ 40 in children 1–5 years old, or (3) signs of severe respiratory distress (accessory muscle use, inability to complete full sentences, and, in children, very severe chest wall indrawing, grunting, central cyanosis, or presence of any other general danger signs. (DO)
Synonyms:related_synonym: SUSCEPTIBILITY TO SEVERE CORONAVIRUS DISEASE (COVID-19) DUE TO HIGH LEVELS OF FIBRINOGEN AND C-REACTIVE PROTEIN;   SUSCEPTIBILITY TO SEVERE COVID-19

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
severe COVID-19 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit ISO ClinVar Annotator: match by term: Susceptibility to severe coronavirus disease (COVID-19) due to high levels of fibrinogen and C-reactive protein ClinVar PMID:18385738 PMID:18385739 PMID:18618000 PMID:19132693 PMID:19443489 More... NCBI chr26:4,747,734...4,779,231
Ensembl chr26:4,749,766...4,776,822 		JBrowse link
G IFIH1 interferon induced with helicase C domain 1 ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar PMID:19264985 PMID:25741868 PMID:28492532 PMID:28716935 PMID:33440462 More... NCBI chr10:47,676,799...47,732,310
Ensembl chr10:47,676,920...47,732,264 		JBrowse link
G IFNAR2 interferon alpha and beta receptor subunit 2 ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar PMID:28492532 NCBI chr 2:58,920,237...58,954,809
Ensembl chr 2:58,918,433...58,954,790 		JBrowse link
G LYST lysosomal trafficking regulator ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar PMID:25741868 PMID:28492532 PMID:33217554 NCBI chr25:72,827,997...73,048,645
Ensembl chr25:72,828,006...72,991,970 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar PMID:25741868 PMID:28492532 PMID:32135276 NCBI chr11:52,297,890...52,316,089
Ensembl chr11:52,297,543...52,316,105 		JBrowse link
G TBK1 TANK binding kinase 1 ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar PMID:25741868 PMID:28492532 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar PMID:28492532 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TLR4 toll like receptor 4 ISO ClinVar Annotator: match by term: Susceptibility to severe COVID-19 ClinVar NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15392
    disease by infectious agent 2092
      viral infectious disease 1606
        RNA Virus Infections 1342
          Nidovirales Infections 989
            Coronaviridae Infections 989
              Coronavirus infectious disease 989
                COVID-19 918
                  severe COVID-19 8
paths to the root