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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bretylium
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Accession:CHEBI:3172 term browser browse the term
Definition:A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Synonyms:exact_synonym: N-(2-bromobenzyl)-N,N-dimethylethanaminium
 related_synonym: (2-bromobenzyl)ethyldimethylaminium;   2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium;   Formula=C11H17BrN;   InChI=1S/C11H17BrN/c1-4-13(2,3)9-10-7-5-6-8-11(10)12/h5-8H,4,9H2,1-3H3/q+1;   InChIKey=AAQOQKQBGPPFNS-UHFFFAOYSA-N;   N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium;   SMILES=CC[N+](C)(C)Cc1ccccc1Br
 xref: Beilstein:4135284;   CAS:59-41-6;   DrugBank:DB01158;   Drug_Central:394;   KEGG:C06855;   LINCS:LSM-5607;   Wikipedia:Bretylium



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bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      molecular entity 20054
        ion 16470
          organic ion 9184
            organic cation 8114
              quaternary ammonium ion 5123
                bretylium 1
                  bretylium tosylate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  ammonium 8235
                                    ammonium ion derivative 8231
                                      quaternary ammonium ion 5123
                                        bretylium 1
                                          bretylium tosylate 1
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