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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bretylium
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Accession:CHEBI:3172 term browser browse the term
Definition:A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Synonyms:exact_synonym: N-(2-bromobenzyl)-N,N-dimethylethanaminium
 related_synonym: (2-bromobenzyl)ethyldimethylaminium;   2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium;   Formula=C11H17BrN;   InChI=1S/C11H17BrN/c1-4-13(2,3)9-10-7-5-6-8-11(10)12/h5-8H,4,9H2,1-3H3/q+1;   InChIKey=AAQOQKQBGPPFNS-UHFFFAOYSA-N;   N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium;   SMILES=CC[N+](C)(C)Cc1ccccc1Br
 xref: Beilstein:4135284;   CAS:59-41-6;   DrugBank:DB01158;   Drug_Central:394;   KEGG:C06855;   LINCS:LSM-5607;   Wikipedia:Bretylium


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bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      molecular entity 19836
        ion 17069
          organic ion 11435
            organic cation 8947
              quaternary ammonium ion 5282
                bretylium 1
                  bretylium tosylate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    main group molecular entity 19806
                      s-block molecular entity 19616
                        hydrogen molecular entity 19596
                          hydrides 19108
                            inorganic hydride 18111
                              pnictogen hydride 18100
                                nitrogen hydride 18008
                                  ammonium 8314
                                    ammonium ion derivative 8300
                                      quaternary ammonium ion 5282
                                        bretylium 1
                                          bretylium tosylate 1
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