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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bretylium
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Accession:CHEBI:3172 term browser browse the term
Definition:A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Synonyms:exact_synonym: N-(2-bromobenzyl)-N,N-dimethylethanaminium
 related_synonym: (2-bromobenzyl)ethyldimethylaminium;   2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium;   Formula=C11H17BrN;   InChI=1S/C11H17BrN/c1-4-13(2,3)9-10-7-5-6-8-11(10)12/h5-8H,4,9H2,1-3H3/q+1;   InChIKey=AAQOQKQBGPPFNS-UHFFFAOYSA-N;   N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium;   SMILES=CC[N+](C)(C)Cc1ccccc1Br
 xref: Beilstein:4135284;   CAS:59-41-6;   DrugBank:DB01158;   Drug_Central:394;   KEGG:C06855;   LINCS:LSM-5607;   Wikipedia:Bretylium


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bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        ion 15918
          organic ion 8320
            organic cation 7133
              quaternary ammonium ion 5079
                bretylium 1
                  bretylium tosylate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  ammonium 8213
                                    ammonium ion derivative 8209
                                      quaternary ammonium ion 5079
                                        bretylium 1
                                          bretylium tosylate 1
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