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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bretylium tosylate
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Accession:CHEBI:3173 term browser browse the term
Definition:The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Synonyms:exact_synonym: N-(2-bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate
 related_synonym: (2-bromobenzyl)ethyldimethylammonium toluene-4-sulfonate;   (2-bromobenzyl)ethyldimethylammonium tosylate;   (o-bromobenzyl)ethyldimethylammonium p-toluenesulfonate;   2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-methylbenzenesulfonate;   Formula=C18H24BrNO3S;   InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1;   InChIKey=KVWNWTZZBKCOPM-UHFFFAOYSA-M;   N-ethyl-N-o-bromobenzyl-N,N-dimethylammonium tosylate;   SMILES=Cc1ccc(cc1)S([O-])(=O)=O.CC[N+](C)(C)Cc1ccccc1Br;   bretylii tosilas;   dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate;   tosilate de bretylium;   tosilato de bretilio
 xref: Beilstein:5702258;   CAS:61-75-6;   DrugBank:DB01158;   KEGG:D00645
 xref_mesh: MESH:D001950
 xref: Patent:US3038004


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bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            cardiovascular drug 7613
              antihypertensive agent 1676
                bretylium tosylate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  ammonium 8213
                                    ammonium ion derivative 8209
                                      ammonium compound 5081
                                        organoammonium salt 420
                                          quaternary ammonium salt 306
                                            bretylium tosylate 1
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