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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bretylium tosylate
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Accession:CHEBI:3173 term browser browse the term
Definition:The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Synonyms:exact_synonym: N-(2-bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate
 related_synonym: (2-bromobenzyl)ethyldimethylammonium toluene-4-sulfonate;   (2-bromobenzyl)ethyldimethylammonium tosylate;   (o-bromobenzyl)ethyldimethylammonium p-toluenesulfonate;   2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-methylbenzenesulfonate;   Formula=C18H24BrNO3S;   InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1;   InChIKey=KVWNWTZZBKCOPM-UHFFFAOYSA-M;   N-ethyl-N-o-bromobenzyl-N,N-dimethylammonium tosylate;   SMILES=Cc1ccc(cc1)S([O-])(=O)=O.CC[N+](C)(C)Cc1ccccc1Br;   bretylii tosilas;   dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate;   tosilate de bretylium;   tosilato de bretilio
 xref: Beilstein:5702258;   CAS:61-75-6;   DrugBank:DB01158;   KEGG:D00645
 xref_mesh: MESH:D001950
 xref: Patent:US3038004



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bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            cardiovascular drug 7705
              antihypertensive agent 1869
                bretylium tosylate 1
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  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            inorganic hydride 17688
                              pnictogen hydride 17668
                                nitrogen hydride 17540
                                  ammonium 8233
                                    ammonium ion derivative 8229
                                      ammonium compound 5086
                                        organoammonium salt 427
                                          quaternary ammonium salt 309
                                            bretylium tosylate 1
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