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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:angiotensin I
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Accession:CHEBI:2718 term browser browse the term
Definition:A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.
Synonyms:exact_synonym: L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine
 related_synonym: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu;   D-R-V-Y-I-H-P-F-H-L;   DRVYIHPFHL;   Formula=C62H89N17O14;   InChI=1S/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1;   InChIKey=ORWYRWWVDCYOMK-HBZPZAIKSA-N;   L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-L-Leu;   SMILES=[C@H](NC([C@H](CC(O)=O)N)=O)(CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CNC=N3)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)CC4=CN=CN4)=O)[C@H](CC)C)=O)CC5=CC=C(C=C5)O)=O)C(C)C)=O;   pepsitensin;   proangiotensin
 xref: CAS:9041-90-1;   HMDB:HMDB0061196;   KEGG:C00873
 xref_mesh: MESH:D000803
 xref: MetaCyc:CPD-13004;   PMID:20026757;   PMID:31746507;   PMID:32028998;   PMID:32238693;   PMID:836506;   Patent:WO2009040072
 cyclic_relationship: is_tautomer_of CHEBI:147350


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angiotensin I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of angiotensin I (1-7); [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin I CTD PMID:27649628 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      biological role 19812
        pharmacological role 19057
          neurotransmitter agent 16742
            angiotensin I 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17696
                                        univalent carboacyl group 17696
                                          carbamoyl group 17546
                                            carboxamide 17546
                                              peptide 11129
                                                peptide hormone 152
                                                  angiotensin 46
                                                    angiotensin I 1
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