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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:semaxanib
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Accession:CHEBI:91083 term browser browse the term
Definition:An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.
Synonyms:exact_synonym: (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
 related_synonym: (Z)-SU 5416;   3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone;   3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole;   3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone;   Formula=C15H14N2O;   InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-;   InChIKey=WUWDLXZGHZSWQZ-WQLSENKSSA-N;   SMILES=N1C(/C(/C=2C=CC=CC12)=C\\C=3NC(=CC3C)C)=O;   SU 5416;   SU5416;   Sugen-5416;   TSU 16
 xref: CAS:194413-58-6;   KEGG:D05819;   PDBeChem:X2M;   PMID:25391620;   PMID:25450973;   PMID:25521760;   PMID:25665868;   PMID:25886469;   PMID:26291195;   PMID:26314590;   PMID:26418615;   PMID:26421302;   PMID:26593399;   PMID:26727223;   PMID:26790474;   PMID:26804178;   PMID:26813102;   Reaxys:7995521;   Wikipedia:Semaxanib


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semaxanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 increases expression EXP semaxanib (SUGEN) increases expression of IL2 mRNA in rat whole lung RGD PMID:23867624 RGD:329848996 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Kdr kinase insert domain receptor EXP su5416, semaxanib, decreases phosphorylation of kdr (vegfr2) protein in rat lung RGD PMID:33836606 RGD:401940192 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Rfc1 replication factor C subunit 1 multiple interactions EXP [Sugen-5416 co-treated with hypoxia] increases expression of Rfc1 protein in the heart right ventricle RGD PMID:22720015 RGD:401940165 NCBI chr14:43,319,768...43,395,028
Ensembl chr14:42,966,324...43,041,370 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19904
    role 19875
      application 19718
        pharmaceutical 19555
          drug 19555
            antineoplastic agent 17839
              semaxanib 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      carbon group element atom 19779
                        carbon atom 19776
                          organic molecular entity 19776
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19219
                                  carbon oxoacid 18698
                                    carboxylic acid 18695
                                      carboacyl group 17723
                                        univalent carboacyl group 17723
                                          carbamoyl group 17568
                                            carboxamide 17568
                                              lactam 8402
                                                gamma-lactam 6664
                                                  oxindoles 5891
                                                    3-methyleneoxindole 5834
                                                      semaxanib 3
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