.
semaxanib - Ontology Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:semaxanib
go back to main search page
Accession:CHEBI:91083 term browser browse the term
Definition:An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.
Synonyms:exact_synonym: (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
 related_synonym: (Z)-SU 5416;   3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone;   3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole;   3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone;   Formula=C15H14N2O;   InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-;   InChIKey=WUWDLXZGHZSWQZ-WQLSENKSSA-N;   SMILES=N1C(/C(/C=2C=CC=CC12)=C\\C=3NC(=CC3C)C)=O;   SU 5416;   SU5416;   Sugen-5416;   TSU 16
 xref: CAS:194413-58-6;   KEGG:D05819;   PDBeChem:X2M;   PMID:25391620;   PMID:25450973;   PMID:25521760;   PMID:25665868;   PMID:25886469;   PMID:26291195;   PMID:26314590;   PMID:26418615;   PMID:26421302;   PMID:26593399;   PMID:26727223;   PMID:26790474;   PMID:26804178;   PMID:26813102;   Reaxys:7995521;   Wikipedia:Semaxanib

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
X

show annotations for term's descendants           Sort by:
semaxanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 increases expression EXP semaxanib (SUGEN) increases expression of IL2 mRNA in rat whole lung RGD PMID:23867624 RGD:329848996 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Kdr kinase insert domain receptor EXP su5416, semaxanib, decreases phosphorylation of kdr (vegfr2) protein in rat lung RGD PMID:33836606 RGD:401940192 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Rfc1 replication factor C subunit 1 multiple interactions EXP [Sugen-5416 co-treated with hypoxia] increases expression of Rfc1 protein in the heart right ventricle RGD PMID:22720015 RGD:401940165 NCBI chr14:43,319,768...43,395,028
Ensembl chr14:42,966,324...43,041,370 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            antineoplastic agent 17832
              semaxanib 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              lactam 8392
                                                gamma-lactam 6657
                                                  oxindoles 5888
                                                    3-methyleneoxindole 5831
                                                      semaxanib 3
paths to the root