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azaribine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azaribine
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Accession:CHEBI:88272 term browser browse the term
Definition:A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.
Synonyms:exact_synonym: 2-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione
 related_synonym: 2',3',5'-Tri-O-acetyl-6-azauridine;   2',3',5'-Triacetyl-6-azauridine;   2-(2',3',5'-Triacetyl-beta-D-ribofuranosyl)-as-triazine-3,5-(2H,4H)-dione;   2-beta-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triacetate;   6-Azauridine 2',3',5'-triacetate;   Formula=C14H17N3O9;   InChI=1S/C14H17N3O9/c1-6(18)23-5-9-11(24-7(2)19)12(25-8(3)20)13(26-9)17-14(22)16-10(21)4-15-17/h4,9,11-13H,5H2,1-3H3,(H,16,21,22)/t9-,11-,12-,13-/m1/s1;   InChIKey=QQOBRRFOVWGIMD-OJAKKHQRSA-N;   SMILES=N=1N(C(NC(C1)=O)=O)[C@@H]2O[C@@H]([C@H]([C@H]2OC(=O)C)OC(C)=O)COC(C)=O;   Triacetyl-6-azauridine;   Triazure;   azaribina;   azaribinum
 xref: CAS:2169-64-4;   Drug_Central:27;   KEGG:D03029;   LINCS:LSM-20874
 xref_mesh: MESH:C100231
 xref: PMID:1036874;   PMID:1096923;   PMID:11600283;   PMID:1173747;   PMID:1243822;   PMID:14023746;   PMID:203231;   PMID:324277;   PMID:5137963;   PMID:5171778;   PMID:5911950;   PMID:6198500;   PMID:766762;   PMID:8570536;   Reaxys:631776

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azaribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO azaribine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Umps uridine monophosphate synthetase increases activity ISO azaribine results in increased activity of UMPS protein CTD PMID:1036874 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        pro-agent 12350
          prodrug 12111
            azaribine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbohydrates and carbohydrate derivatives 15436
                                    carbohydrate 15436
                                      carbohydrate derivative 14453
                                        glycosyl compound 13161
                                          N-glycosyl compound 5900
                                            N-glycosyl-1,2,4-triazine 2
                                              6-azauridine 2
                                                azaribine 2
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