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azaribine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azaribine
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Accession:CHEBI:88272 term browser browse the term
Definition:A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.
Synonyms:exact_synonym: 2-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione
 related_synonym: 2',3',5'-Tri-O-acetyl-6-azauridine;   2',3',5'-Triacetyl-6-azauridine;   2-(2',3',5'-Triacetyl-beta-D-ribofuranosyl)-as-triazine-3,5-(2H,4H)-dione;   2-beta-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triacetate;   6-Azauridine 2',3',5'-triacetate;   Formula=C14H17N3O9;   InChI=1S/C14H17N3O9/c1-6(18)23-5-9-11(24-7(2)19)12(25-8(3)20)13(26-9)17-14(22)16-10(21)4-15-17/h4,9,11-13H,5H2,1-3H3,(H,16,21,22)/t9-,11-,12-,13-/m1/s1;   InChIKey=QQOBRRFOVWGIMD-OJAKKHQRSA-N;   SMILES=N=1N(C(NC(C1)=O)=O)[C@@H]2O[C@@H]([C@H]([C@H]2OC(=O)C)OC(C)=O)COC(C)=O;   Triacetyl-6-azauridine;   Triazure;   azaribina;   azaribinum
 xref: CAS:2169-64-4;   Drug_Central:27;   KEGG:D03029;   LINCS:LSM-20874
 xref_mesh: MESH:C100231
 xref: PMID:1036874;   PMID:1096923;   PMID:11600283;   PMID:1173747;   PMID:1243822;   PMID:14023746;   PMID:203231;   PMID:324277;   PMID:5137963;   PMID:5171778;   PMID:5911950;   PMID:6198500;   PMID:766762;   PMID:8570536;   Reaxys:631776

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azaribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO azaribine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Umps uridine monophosphate synthetase increases activity ISO azaribine results in increased activity of UMPS protein CTD PMID:1036874 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        pro-agent 11560
          prodrug 11304
            azaribine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbohydrates and carbohydrate derivatives 15309
                                    carbohydrate 15309
                                      carbohydrate derivative 14335
                                        glycosyl compound 13075
                                          N-glycosyl compound 5884
                                            N-glycosyl-1,2,4-triazine 2
                                              6-azauridine 2
                                                azaribine 2
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