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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acridine orange free base
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Accession:CHEBI:87346 term browser browse the term
Definition:A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.
Synonyms:exact_synonym: N(3),N(3),N(6),N(6)-tetramethylacridine-3,6-diamine
 related_synonym: 3,6-Bis(dimethylamino)acridine;   3,6-Di(dimethylamino)acridine;   Acridine Orange;   Acridine Orange Base;   Brilliant Acridine Orange E;   C.I. 46005B;   C.I. Solvent Orange 15;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14/h5-11H,1-4H3;   InChIKey=DPKHZNPWBDQZCN-UHFFFAOYSA-N;   N,N,N',N'-Tetramethyl-3,6-acridinediamine;   SMILES=CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C;   Solvent Orange 15
 xref: CAS:494-38-2
 xref_mesh: MESH:D000165
 xref: PMID:24988915;   PMID:25025314;   PMID:25542136;   PMID:26016416;   PMID:26034308;   PMID:26163789;   Reaxys:20916;   Wikipedia:Acridine_orange


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acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      application 19663
        dye 2973
          histological dye 255
            acridine orange free base 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic heterocyclic compound 18870
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15657
                                      dibenzopyridine 175
                                        acridines 138
                                          aminoacridines 17
                                            acridine orange free base 3
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