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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acridines
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Accession:CHEBI:22213 term browser browse the term
Synonyms:xref_mesh: MESH:D000166


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acridines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP
ISO
Acridines binds to and results in increased activity of AHR protein CTD PMID:21431309 PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor multiple interactions ISO Acridines inhibits the reaction [Androgens results in increased activity of AR protein] CTD PMID:28377212 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Casp3 caspase 3 increases activity ISO Acridines analog results in increased activity of CASP3 protein CTD PMID:15603970 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Acridines results in decreased activity of CES1 protein CTD PMID:23123248 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Acridines results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan]
Acridines analog results in decreased activity of CYP1A2 protein
CTD PMID:16120190 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Acridines metabolite results in increased expression of GADD45A protein; Acridines results in increased expression of GADD45A protein CTD PMID:31051210 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
3,6-diaminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Proflavine results in increased activity of ESR1 protein CTD PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Proflavine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Proflavine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Proflavine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Proflavine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:30818834 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Proflavine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Proflavine inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Tp53 tumor protein p53 increases activity ISO Proflavine results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding ISO Aminacrine binds to ACHE protein CTD PMID:31176713 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions
ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
amsacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Amsacrine analog binds to ALB protein; Amsacrine binds to ALB protein CTD PMID:10803926 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO Amsacrine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Amsacrine CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to Amsacrine CTD PMID:10920913 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp2 caspase 2 increases splicing
increases expression
ISO Amsacrine results in increased splicing of CASP2 mRNA
Amsacrine results in increased expression of CASP2 mRNA alternative form
CTD PMID:14757846 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Amsacrine results in increased degradation of and results in decreased expression of CCNA2 protein CTD PMID:11774253 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Amsacrine results in increased degradation of and results in decreased expression of CCNB1 protein CTD PMID:11774253 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Amsacrine results in increased expression of CCNE1 protein CTD PMID:11774253 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine CTD PMID:16969495 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Amsacrine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amsacrine binds to and results in decreased activity of KCNH2 protein CTD PMID:15148258 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases activity
affects response to substance
multiple interactions
ISO Amsacrine results in increased activity of MAPK12 protein
MAPK12 protein affects the susceptibility to Amsacrine
[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine
CTD PMID:21878638 NCBI chr 7:130,109,214...130,120,918
Ensembl chr 7:130,109,663...130,120,579
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Amsacrine results in decreased expression of MYC mRNA CTD PMID:11585056 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncl nucleolin affects response to substance ISO NCL protein affects the susceptibility to Amsacrine CTD PMID:16600179 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Amsacrine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Amsacrine results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Rad51 RAD51 recombinase affects response to substance ISO RAD51 protein affects the susceptibility to Amsacrine CTD PMID:16600179 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Amsacrine results in increased expression of RARB mRNA alternative form CTD PMID:17608728 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Amsacrine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Amsacrine results in increased expression of TNFRSF11B mRNA CTD PMID:11459812 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Amsacrine results in decreased expression of TNFSF11 mRNA CTD PMID:11459812 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
affects response to substance
decreases response to substance
ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine; [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine
TOP2A protein modified form affects the susceptibility to Amsacrine
TOP2A gene mutant form results in decreased susceptibility to Amsacrine; TOP2A protein mutant form results in decreased susceptibility to Amsacrine
CTD PMID:1651812 PMID:10727526 PMID:11470519 PMID:11676865 PMID:12569090 PMID:16969495 PMID:21878638 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta decreases response to substance ISO TOP2B protein mutant form results in decreased susceptibility to Amsacrine CTD PMID:15322234 PMID:16239602 PMID:16549872 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 increases activity
increases glutathionylation
multiple interactions
increases expression
ISO Amsacrine analog results in increased activity of TP53 protein
Amsacrine results in increased glutathionylation of TP53 protein
Amsacrine results in increased stability of and results in increased activity of TP53 protein
Amsacrine results in increased expression of TP53 protein
CTD PMID:11774253 PMID:12082016 PMID:16177561 PMID:17555331 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Amsacrine results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Amsacrine results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Wrn WRN RecQ like helicase increases response to substance ISO WRN gene mutant form results in increased susceptibility to Amsacrine CTD PMID:10725663 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375
JBrowse link
clomacran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clomacran inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
ethacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Ethacridine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Ethacridine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of Quinacrine
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of Quinacrine]
CTD PMID:16581945 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agt angiotensinogen multiple interactions ISO Quinacrine inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid] CTD PMID:16257180 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
increases expression
multiple interactions
ISO BAX protein results in increased susceptibility to Quinacrine
Quinacrine results in increased expression of BAX mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of BAX mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of BAX protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]; mithramycin A inhibits the reaction [Quinacrine results in increased expression of BAX mRNA]; mithramycin A inhibits the reaction [Quinacrine results in increased expression of BAX protein]; Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]; Quinacrine results in increased expression of and affects the localization of BAX protein
CTD PMID:16177561 PMID:28867437 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of BTRC protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased expression of BTRC protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]; MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]; Quinacrine results in decreased expression of and results in decreased stability of BTRC mRNA
CTD PMID:28867437 NCBI chr 1:265,100,094...265,270,263
Ensembl chr 1:265,157,379...265,269,837
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO Quinacrine results in increased cleavage of CASP3 protein
GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]
CTD PMID:28720477 PMID:28867437 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Quinacrine results in increased cleavage of CASP9 protein CTD PMID:28867437 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of CCND1 protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]
CTD PMID:28720477 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 increases expression
multiple interactions
ISO Quinacrine results in increased expression of CSNK1A1 protein
GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]
CTD PMID:28720477 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein] CTD PMID:28720477 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
EXP Quinacrine binds to and results in decreased activity of CYP2E1 protein
Quinacrine results in decreased expression of CYP2E1 protein
CTD PMID:18754103 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Foxp3 forkhead box P3 increases expression
multiple interactions
ISO Quinacrine results in increased expression of FOXP3 mRNA; Quinacrine results in increased expression of FOXP3 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 protein]; FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]
CTD PMID:28867437 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of GLI1 protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]
CTD PMID:28720477 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Quinacrine results in increased expression of GSK3B mRNA
GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]; GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]; GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]; Quinacrine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:28720477 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Quinacrine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO Quinacrine results in decreased phosphorylation of MAPK1 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]
CTD PMID:28867437 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Quinacrine results in decreased phosphorylation of MAPK3 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]
CTD PMID:28867437 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir183 microRNA 183 multiple interactions
increases expression
ISO FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]; MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]; MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein] CTD PMID:28867437 NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of MYC protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]
CTD PMID:28720477 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Quinacrine binds to and results in decreased activity of NQO2 protein CTD PMID:15078100 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Otc ornithine transcarbamylase multiple interactions EXP Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein]; Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Quinacrine results in increased cleavage of PARP1 protein CTD PMID:28867437 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prl prolactin multiple interactions EXP Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]; MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein]; Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]; Quinacrine results in increased expression of and results in increased stability of SP1 protein CTD PMID:28867437 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions
ISO Quinacrine results in increased activity of TP53 protein
Quinacrine results in increased stability of and results in increased activity of TP53 protein
CTD PMID:12082016 PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
tacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tacrine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
Tacrine results in decreased activity of ACHE protein
Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ALB protein affects the reaction [Tacrine results in decreased activity of ACHE protein]
Tacrine analog results in decreased activity of ACHE protein; Tacrine results in decreased activity of ACHE protein
CTD PMID:2606156 PMID:9228650 PMID:12589378 PMID:15990178 PMID:18571635 PMID:19053746 PMID:19365154 PMID:26902639 PMID:29131470 PMID:29975450 PMID:29992664 PMID:31077737 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression EXP Tacrine results in increased expression of ADCYAP1R1 mRNA CTD PMID:12832660 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Tacrine results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Tacrine inhibits the reaction [Staurosporine results in increased expression of BAX protein]
Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]
CTD PMID:12414117 PMID:12579951 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Tacrine results in decreased activity of BCHE protein CTD PMID:9228650 PMID:18656440 PMID:29992664 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Tacrine results in increased expression of BCL2 protein CTD PMID:12579951 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein] CTD PMID:26408985 PMID:31077737 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cat catalase multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:31077737 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Tacrine results in decreased expression of CCL5 mRNA CTD PMID:12832660 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Tacrine results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces1d carboxylesterase 1D decreases activity
affects binding
ISO Tacrine analog results in decreased activity of CES1 protein
Tacrine binds to CES1 protein
CTD PMID:12725862 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Tacrine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chat choline O-acetyltransferase increases expression ISO Tacrine results in increased expression of CHAT protein CTD PMID:15990178 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP
ISO
Tacrine inhibits the reaction [telenzepine binds to CHRM1 protein]
Tacrine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:2606156 PMID:16439611 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP Tacrine inhibits the reaction [otenzepad binds to CHRM2 protein] CTD PMID:2606156 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
increases expression
ISO Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Tacrine results in increased expression of CHRNA4 protein
Mecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNA4 protein]
CTD PMID:8930989 PMID:15733544 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression
ISO Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Tacrine results in increased expression of CHRNB2 protein
Mecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNB2 protein]
CTD PMID:8930989 PMID:15733544 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:31077737 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cspp1 centrosome and spindle pole associated protein 1 increases expression EXP Tacrine results in increased expression of CSPP1 mRNA CTD PMID:12832660 NCBI chr 5:8,761,293...8,876,205
Ensembl chr 5:8,761,293...8,864,578
JBrowse link
G Cwf19l2 CWF19 like cell cycle control factor 2 increases expression EXP Tacrine results in increased expression of CWF19L2 mRNA CTD PMID:12832660 NCBI chr 6:18,970,616...19,037,176
Ensembl chr 6:18,970,564...19,055,924
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
affects metabolic processing
multiple interactions
EXP
ISO
Tacrine analog results in increased expression of CYP1A1 protein; Tacrine results in increased expression of CYP1A1 mRNA; Tacrine results in increased expression of CYP1A1 protein
CYP1A1 protein affects the metabolism of Tacrine
Tacrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:12832660 PMID:15258105 PMID:18493746 PMID:20533758 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing
ISO
EXP
Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; NADP promotes the reaction [Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; Tacrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Tacrine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Tacrine
CTD PMID:7946932 PMID:15258105 PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Tacrine analog results in increased expression of CYP2B1 protein; Tacrine results in increased expression of CYP2B1 protein CTD PMID:20533758 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Tacrine analog results in increased expression of CYP3A2 protein; Tacrine results in increased expression of CYP3A2 protein CTD PMID:20533758 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases response to substance ISO CYP3A4 protein results in increased susceptibility to Tacrine CTD PMID:21540358 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Tacrine results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression EXP Tacrine results in increased expression of DLG2 mRNA CTD PMID:12832660 NCBI chr 1:154,916,274...157,274,077
Ensembl chr 1:156,552,328...157,269,747
JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 increases expression EXP Tacrine results in increased expression of DNAH8 mRNA CTD PMID:12832660 NCBI chr20:9,301,317...9,560,805
Ensembl chr20:9,313,271...9,560,682
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression EXP Tacrine results in increased expression of DYNC1LI2 mRNA CTD PMID:12832660 NCBI chr19:740,007...762,897
Ensembl chr19:740,028...762,897
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Tacrine results in increased expression of FOS protein
zonisamide inhibits the reaction [Tacrine results in increased expression of FOS protein]
CTD PMID:18693129 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Tacrine results in increased expression of GABRA4 mRNA CTD PMID:12832660 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Tacrine results in increased expression of GATA3 mRNA CTD PMID:12832660 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein] CTD PMID:26408985 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Tacrine results in increased expression of GSTM2 mRNA CTD PMID:12832660 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Tacrine results in increased expression of HGF mRNA CTD PMID:12832660 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Tacrine analog results in increased expression of HMOX1 protein; Tacrine results in increased expression of HMOX1 protein CTD PMID:20533758 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:2606156 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Ibsp integrin-binding sialoprotein increases expression EXP Tacrine results in increased expression of IBSP mRNA CTD PMID:12832660 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] CTD PMID:31077737 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein] CTD PMID:31077737 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein] CTD PMID:31077737 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Tacrine results in increased expression of ITGAM mRNA CTD PMID:12832660 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Tacrine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Tacrine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 increases expression EXP Tacrine results in increased expression of KLK1C9 mRNA CTD PMID:12832660 NCBI chr 1:100,086,520...100,090,406
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Lepr leptin receptor increases expression EXP Tacrine results in increased expression of LEPR mRNA CTD PMID:12832660 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mybpc1 myosin binding protein C1 decreases expression EXP Tacrine results in decreased expression of MYBPC1 mRNA CTD PMID:12832660 NCBI chr 7:29,086,159...29,171,909
Ensembl chr 7:29,086,156...29,171,783
JBrowse link
G Neurod1 neuronal differentiation 1 increases expression EXP Tacrine results in increased expression of NEUROD1 mRNA CTD PMID:12832660 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP Tacrine results in increased expression of NOS1 mRNA CTD PMID:9500967 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:31077737 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression EXP Tacrine results in increased expression of NPY5R mRNA CTD PMID:12832660 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases activity
ISO Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
Tacrine results in decreased activity of NQO1 protein
CTD PMID:29281794 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 decreases activity
multiple interactions
ISO Tacrine results in decreased activity of NQO2 protein
Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of amodiaquine quinoneimine]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]
CTD PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein CTD PMID:31077737 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP
ISO
Tacrine results in increased expression of PTGS2 protein
Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
CTD PMID:9500967 PMID:31077737 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 increases expression EXP Tacrine results in increased expression of SCN1A mRNA CTD PMID:12832660 NCBI chr 3:52,388,811...52,533,365
Ensembl chr 3:52,381,975...52,510,507
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tacrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Tacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tacrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tacrine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tacrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Slc6a1 solute carrier family 6 member 1 increases expression EXP Tacrine results in increased expression of SLC6A1 mRNA CTD PMID:12832660 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
G Snca synuclein alpha decreases expression EXP Tacrine results in decreased expression of SNCA mRNA CTD PMID:12832660 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Syn2 synapsin II increases expression EXP Tacrine results in increased expression of SYN2 mRNA CTD PMID:12832660 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein] CTD PMID:31077737 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf4 TNF superfamily member 4 increases expression EXP Tacrine results in increased expression of TNFSF4 mRNA CTD PMID:12832660 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]; Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] CTD PMID:12414117 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                organonitrogen heterocyclic compound 17564
                  dibenzopyridine 155
                    acridines 122
                      (9-chloro-5,6,7,8-tetrahydroacridin-3-yl)-(4-methyl-1-piperidinyl)methanone 0
                      1,2,3,4-tetrahydroacridine-9-carboxylic acid (2-oxo-2-thiophen-2-ylethyl) ester 0
                      1,2,3,4-tetrahydroacridine-9-carboxylic acid [2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester 0
                      1,3-dichloro-7-hydroxy-9,9-dimethyl-9H-acridin-2-one 0
                      1,3-dihydroxy-N-methylacridone 0
                      1,4-dimethoxy-10H-acridine-9-thione 0
                      1,5-Dihydroxy-2,3-dimethoxy-10-methyl-9-acridone 0
                      1-methoxy-10H-acridin-9-one 0
                      10-(3-aminopropyl)-3,4-dimethyl-9-acridinone 0
                      10-[3-(dibutylamino)-2-hydroxypropyl]-9-acridinone 0
                      2-Aminoacridone 0
                      2-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)thio]-N-(3-methoxypropyl)acetamide 0
                      2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acid 0
                      2-tert-butyl-9-methyl-1,2,3,4-tetrahydroacridine 0
                      3,9,11-Trichloro-5,6-dihydro-7-[1-hydroxy-2-[1-piperidyl]ethyl]benz[c]acridine 0
                      3-pyrrolidin-1-yl-N-[6-(3-pyrrolidin-1-ylpropionylamino)acridin-3-yl]propionamide 0
                      4-(9-acridinylamino)-1,5-dimethyl-2-phenyl-3-pyrazolone 0
                      4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid (2-anilino-2-oxoethyl) ester 0
                      4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid [2-(4-acetylanilino)-2-oxoethyl] ester 0
                      4-[(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-1,2,3,10-tetrahydroacridine-9-carboxylic acid 0
                      5-Hydroxynoracronycine 0
                      9-(1H-indol-3-yl)acridine 0
                      9-Amino-1,2,3,4-tetrahydro-acridinium 0
                      9-amino-1,2,3,4-tetrahydroacridin-1-ol 0
                      9-amino-N-(2-morpholin-4-ylethyl)acridine-4-carboxamide 0
                      Arborinine 0
                      Atalanine 0
                      Atalaphylline 0
                      Buntanine 0
                      Evoprenine 0
                      Evoxanthidine 0
                      Furofoline I 0
                      ICR-170 0
                      LSM-18565 0
                      Melicopicine 0
                      Melicopine 0
                      N'-(9-acridinyl)-2-(3-methylphenoxy)acetohydrazide 0
                      N'-(9-acridinyl)-2-hydroxybenzohydrazide 0
                      N,N'-(9-\{[4-(dimethylamino)phenyl]amino\}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide) + 0
                      N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine + 0
                      N-(3-fluorophenyl)-2-(9-oxo-10-acridinyl)acetamide 0
                      N-[(10-methyl-9,10-dihydroacridin-9-yl)carbonyl]-beta-alanine 0
                      N-[4-(9-acridinylmethyl)-3-methoxyphenyl]methanesulfonamide 0
                      Rutacridone 0
                      Rutacridone epoxide 0
                      acridine + 29
                      acridone + 0
                      aminoacridines + 17
                      amsacrine 28
                      asulacrine 0
                      bucricaine 0
                      clomacran 1
                      cridanimod 0
                      dimetacrine 0
                      ethacridine 1
                      nitracrine 0
                      quinacrine + 29
                      tacrine + 66
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heterotricyclic compound 14589
                                      dibenzopyridine 155
                                        acridines 122
                                          (9-chloro-5,6,7,8-tetrahydroacridin-3-yl)-(4-methyl-1-piperidinyl)methanone 0
                                          1,2,3,4-tetrahydroacridine-9-carboxylic acid (2-oxo-2-thiophen-2-ylethyl) ester 0
                                          1,2,3,4-tetrahydroacridine-9-carboxylic acid [2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester 0
                                          1,3-dichloro-7-hydroxy-9,9-dimethyl-9H-acridin-2-one 0
                                          1,3-dihydroxy-N-methylacridone 0
                                          1,4-dimethoxy-10H-acridine-9-thione 0
                                          1,5-Dihydroxy-2,3-dimethoxy-10-methyl-9-acridone 0
                                          1-methoxy-10H-acridin-9-one 0
                                          10-(3-aminopropyl)-3,4-dimethyl-9-acridinone 0
                                          10-[3-(dibutylamino)-2-hydroxypropyl]-9-acridinone 0
                                          2-Aminoacridone 0
                                          2-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)thio]-N-(3-methoxypropyl)acetamide 0
                                          2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acid 0
                                          2-tert-butyl-9-methyl-1,2,3,4-tetrahydroacridine 0
                                          3,9,11-Trichloro-5,6-dihydro-7-[1-hydroxy-2-[1-piperidyl]ethyl]benz[c]acridine 0
                                          3-pyrrolidin-1-yl-N-[6-(3-pyrrolidin-1-ylpropionylamino)acridin-3-yl]propionamide 0
                                          4-(9-acridinylamino)-1,5-dimethyl-2-phenyl-3-pyrazolone 0
                                          4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid (2-anilino-2-oxoethyl) ester 0
                                          4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid [2-(4-acetylanilino)-2-oxoethyl] ester 0
                                          4-[(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-1,2,3,10-tetrahydroacridine-9-carboxylic acid 0
                                          5-Hydroxynoracronycine 0
                                          9-(1H-indol-3-yl)acridine 0
                                          9-Amino-1,2,3,4-tetrahydro-acridinium 0
                                          9-amino-1,2,3,4-tetrahydroacridin-1-ol 0
                                          9-amino-N-(2-morpholin-4-ylethyl)acridine-4-carboxamide 0
                                          Arborinine 0
                                          Atalanine 0
                                          Atalaphylline 0
                                          Buntanine 0
                                          Evoprenine 0
                                          Evoxanthidine 0
                                          Furofoline I 0
                                          ICR-170 0
                                          LSM-18565 0
                                          Melicopicine 0
                                          Melicopine 0
                                          N'-(9-acridinyl)-2-(3-methylphenoxy)acetohydrazide 0
                                          N'-(9-acridinyl)-2-hydroxybenzohydrazide 0
                                          N,N'-(9-\{[4-(dimethylamino)phenyl]amino\}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide) + 0
                                          N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine + 0
                                          N-(3-fluorophenyl)-2-(9-oxo-10-acridinyl)acetamide 0
                                          N-[(10-methyl-9,10-dihydroacridin-9-yl)carbonyl]-beta-alanine 0
                                          N-[4-(9-acridinylmethyl)-3-methoxyphenyl]methanesulfonamide 0
                                          Rutacridone 0
                                          Rutacridone epoxide 0
                                          acridine + 29
                                          acridone + 0
                                          aminoacridines + 17
                                          amsacrine 28
                                          asulacrine 0
                                          bucricaine 0
                                          clomacran 1
                                          cridanimod 0
                                          dimetacrine 0
                                          ethacridine 1
                                          nitracrine 0
                                          quinacrine + 29
                                          tacrine + 66
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