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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sofosbuvir
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Accession:CHEBI:85083 term browser browse the term
Definition:A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
Synonyms:related_synonym: Formula=C22H29FN3O9P;   GI 7977;   GS-7977;   InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1;   InChIKey=TTZHDVOVKQGIBA-IQWMDFIBSA-N;   PSI-7977;   SMILES=CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1;   Sovaldi;   isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
 xref: CAS:1190307-88-0;   Drug_Central:4811;   KEGG:D10366;   PMID:25123381;   PMID:25159822;   PMID:25261839;   PMID:25304641;   PMID:25322962;   PMID:25583164;   PMID:25601269;   PMID:25614962;   PMID:25619265;   PMID:25621961;   PMID:25622055;   PMID:25641426;   PMID:25645644;   PMID:25659285;   PMID:25674516;   PMID:25676703;   PMID:25708155;   Reaxys:20867484;   Wikipedia:Sofosbuvir


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sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        pro-agent 11548
          prodrug 11310
            sofosbuvir 2
              Epclusa 0
              Harvoni 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      chalcogen 19614
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              oxoacid 18823
                                pnictogen oxoacid 14983
                                  phosphorus oxoacid 14581
                                    phosphoric acids 13923
                                      phosphoric acid 13923
                                        phosphoric acid derivative 13829
                                          phosphate 13828
                                            organic phosphate 13828
                                              carbohydrate phosphate 1871
                                                phospho sugar 1716
                                                  aldose phosphate 1713
                                                    aldopentose phosphate 1705
                                                      ribose phosphate 1700
                                                        ribonucleotide 1662
                                                          ribonucleoside 5'-phosphate 652
                                                            ribonucleoside 5'-monophosphate 366
                                                              pyrimidine ribonucleoside 5'-monophosphate 330
                                                                uridine 5'-monophosphate 3
                                                                  sofosbuvir 2
                                                                    Epclusa 0
                                                                    Harvoni 0
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