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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:85083 term browser browse the term
Definition:A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
Synonyms:related_synonym: Formula=C22H29FN3O9P;   GI 7977;   GS-7977;   InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1;   InChIKey=TTZHDVOVKQGIBA-IQWMDFIBSA-N;   PSI-7977;   SMILES=CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1;   Sovaldi;   isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
 xref: CAS:1190307-88-0;   Drug_Central:4811;   KEGG:D10366;   PMID:25123381;   PMID:25159822;   PMID:25261839;   PMID:25304641;   PMID:25322962;   PMID:25583164;   PMID:25601269;   PMID:25614962;   PMID:25619265;   PMID:25621961;   PMID:25622055;   PMID:25641426;   PMID:25645644;   PMID:25659285;   PMID:25674516;   PMID:25676703;   PMID:25708155;   Reaxys:20867484;   Wikipedia:Sofosbuvir

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sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        pro-agent 8879
          prodrug 8633
            sofosbuvir 2
              Epclusa 0
              Harvoni 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      chalcogen 19394
                        oxygen atom 19357
                          oxygen molecular entity 19357
                            hydroxides 19080
                              oxoacid 18279
                                pnictogen oxoacid 10309
                                  phosphorus oxoacid 9231
                                    phosphoric acids 7952
                                      phosphoric acid 7952
                                        phosphoric acid derivative 7632
                                          phosphate 7632
                                            organic phosphate 7631
                                              carbohydrate phosphate 1714
                                                phospho sugar 1639
                                                  aldose phosphate 1637
                                                    aldopentose phosphate 1631
                                                      ribose phosphate 1626
                                                        ribonucleotide 1587
                                                          ribonucleoside 5'-phosphate 601
                                                            ribonucleoside 5'-monophosphate 337
                                                              pyrimidine ribonucleoside 5'-monophosphate 311
                                                                uridine 5'-monophosphate 2
                                                                  sofosbuvir 2
                                                                    Epclusa 0
                                                                    Harvoni 0
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